Effect of Propofol on breast Cancer cell, the immune system, and patient outcome.
Effect of Propofol on breast Cancer cell, the immune system, and patient outcome.
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DOI：
10.1186/s12871-018-0543-3
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发表时间：
2018-06-26
影响因子：
2.2
通讯作者：
Lin J
中科院分区：
文献类型：
--
作者：
Li R;Liu H;Dilger JP;Lin J
乳腺癌是妇女癌症死亡的第二大原因。手术是治疗乳腺癌的第一线。回顾性临床研究表明，在肿瘤手术期间给予的麻醉类型可能会影响患者的结局。异丙酚，广泛使用的静脉麻醉剂，可能会导致更好的结果相比，挥发性麻醉剂。在此，我们回顾了丙泊酚对乳腺癌细胞、免疫系统、疼痛管理和患者预后的影响。来自乳腺癌细胞系研究的证据表明，高浓度的丙泊酚具有抗肿瘤和促肿瘤作用。异丙酚和挥发性麻醉药对免疫系统有不同的影响。异丙酚也被证明可以减少手术后急性和慢性疼痛的发展和严重程度。尽管一项包括多种癌症的回顾性研究表明，丙泊酚可以增加手术后患者的长期生存率，但在乳腺癌中的证据还很薄弱。研究表明，异丙酚联合椎旁阻滞可引起血清成分的改变，从而影响乳腺癌细胞的行为和自然杀伤细胞的活性。前瞻性研究正在进行中，将在5年内完成。现有证据不足以保证改变当前的麻醉管理。需要进一步的研究来阐明丙泊酚影响癌细胞和免疫系统的机制。
Breast cancer is the second leading cause of cancer death in women. Surgery is the first line of treatment for breast cancer. Retrospective clinical studies suggest that the type of anesthesia administered during oncological surgery may influence patient outcome. Propofol, the widely used intravenous anesthetic agent, may lead to better outcomes compared to volatile anesthetics. Here we review the literature on the effect of propofol in breast cancer cells, the immune system, pain management, and patient outcomes. Evidence from the study of breast cancer cell lines suggests that high concentrations of propofol have both anti-tumor and pro-tumor effects. Propofol and volatile anesthetics have different effects on the immune system. Propofol has also been shown to reduce the development and severity of acute and chronic pain following surgery. Although a retrospective study that included many types of cancer indicated that propofol increases the long-term survival of patients following surgery, the evidence for this in breast cancer is weak. It has been shown that Propofol combined with paravertebral block led to change of serum composition that affects the breast cancer cell behaviors and natural killer cell activity. Prospective studies are in progress and will be finished within 5 years. The existing evidence is not sufficient to warrant changes to current anesthetic management. Further research is needed to clarify the mechanisms by which propofol affects cancer cells and the immune system.
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DOI：
10.1046/j.1460-9592.2001.00731.x
发表时间：
2001-09-01
期刊：
PAEDIATRIC ANAESTHESIA
影响因子：
--
作者：
Hammer, GB;Litalien, C;Drover, DR
通讯作者：
Drover, DR
影响因子：
5.1
作者：
Deegan, Catherine A.;Murray, David;Buggy, Donal J.
通讯作者：
Buggy, Donal J.
影响因子：
9.8
作者：
Jaura, A. I.;Flood, G.;Buggy, D. J.
通讯作者：
Buggy, D. J.
影响因子：
3.4
作者：
Enlund M;Berglund A;Andreasson K;Cicek C;Enlund A;Bergkvist L
通讯作者：
Bergkvist L
影响因子：
5.7
作者：
Cho, Ah-Reum;Kwon, Jae-Young;Kim, Choongrak
通讯作者：
Kim, Choongrak