Massive hemorrhagic functional adrenal adenoma histologically mimicking angiosarcoma. Report of a case with immunohistochemical study.
Massive hemorrhagic functional adrenal adenoma histologically mimicking angiosarcoma. Report of a case with immunohistochemical study.
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大量出血性功能性肾上腺腺瘤组织学上类似于血管肉瘤。
DOI：
10.1097/00000478-199107000-00012
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Curt Collins
中科院分区：
文献类型：
--
作者：
J. Granger;H. Houn;Curt Collins
我们报告了一例大量出血/血栓形成的功能性肾上腺腺瘤，这是一种非常罕见的肾上腺肿块病变。病变包含大片区域，组织学上类似于血管肉瘤的模式。免疫组织化学染色证实血管衬里细胞Vimentin阳性，3种血管标志物(因子VIII抗原、Ulex uropaeus凝集素I、血栓调节蛋白)、细胞角蛋白、角蛋白、上皮膜抗原和S100抗原阴性。血管内皮细胞免疫组织化学标记物可作为鉴别这类反应性出血/血栓病变与血管肉瘤的辅助诊断指标。
We report the case of a massive hemorrhagic/thrombosed functional adrenal adenoma, a very uncommon mass lesion of the adrenal gland. The lesion contained large areas that histologically mimicked the pattern of an angiosarcoma. Immunoperoxidase staining confirmed that the vascular lining cells were positive for vimentin and negative for three vascular markers (factor VIII antigen, Ulex europaeus agglutinin I, thrombomodulin), cytokeratin, keratin, epithelial membrane antigen, and S100 antigen. Endothelial immunohistochemical markers can be useful as a diagnostic adjunct in differentiating this type of reactive hemorrhagic/thrombotic lesion from angiosarcoma.