Genetic trace metal disturbances.
Genetic trace metal disturbances.
复制标题
遗传微量金属干扰。
DOI：
10.1080/07315724.1985.10720065
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发表时间：
1985
影响因子：
3.5
通讯作者：
Rennert,OM
中科院分区：
文献类型：
--
作者：
Chan,WY;Rennert,OM
遗传微量金属干扰可以在三个层次。微量金属在遗传大分子代谢和信息传递系统中起着重要作用。由于饮食或遗传因素导致的微量金属缺乏或过量都会影响整个生物体的正常功能。微量金属在致癌/致突变和衰老中的作用是这一类的典型。第二层次的遗传微量金属干扰影响微量金属本身的代谢途径。遗传缺陷导致的生化紊乱会引起元素的异常代谢，从而引起疾病症状。铜，锌，铁，钼代谢异常引起的疾病进行了讨论。微量金属干扰也可能是其他遗传疾病的结果。这方面的遗传微量金属干扰的研究最少。然而，信息应该是重要的，以改善现有的治疗方案，更常见的先天性代谢缺陷，如苯丙酮尿症。
Genetic trace metal disturbances can be at three levels. Trace metals play an important role in the metabolism of genetic macromolecules and the information transfer system. Deficiency or excess of trace metals caused either by dietary or genetic factors will affect the normal functioning of the whole organism. The roles of trace metals in carcinogenesis/mutagenesis and ageing are typical of this category. The second level of genetic trace metal disturbances affect the metabolic pathway of the trace metal itself. Biochemical derangement resulting from genetic defects cause aberrant metabolism of the element and thus disease symptoms. Diseases caused by abnormal metabolism of copper, zinc, iron, and molybdenum are discussed. Trace metal disturbances can also be the result of other genetic diseases. This aspect of genetic trace metal disturbances is least investigated. However, information should be important for improving the existing treatment protocol for the more common inborn errors of metabolism, such as phenylketonuria.