DBS therapy for a persistent vegetative state: ten years follow-up results.
DBS therapy for a persistent vegetative state: ten years follow-up results.
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DBS 疗法治疗持续性植物人状态：十年随访结果。
DOI：
10.1007/978-3-7091-6081-7_4
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
C. Fukaya
中科院分区：
文献类型：
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作者：
Takamitsu Yamamoto;Yoichi Katayama;Kazutaka Kobayashi;M. Kasai;H. Oshima;C. Fukaya
本文对21例因各种脑损伤所致的持续植物状态（PVS）患者于伤后3个月进行神经和电生理检查。21例患者均行脑深部电刺激治疗，随访10年以上。刺激部位为中脑网状结构（2例）和CM-pf复合体（19例）。其中8名患者从PVS中出来，并能够服从口头命令。然而，他们仍然处于卧床不起的状态。这8例患者在连续EEG频率分析上显示去极化。ABR的Vth波和SEP的N20在潜伏期延长的情况下也能记录到，疼痛相关的P250的振幅超过7 µV。8例中位生存期为6.1年，其余13例中位生存期为3.1年。总的来说，4例病例在10年后仍然存活。如果根据神经生理学标准选择候选者，DBS治疗可能有助于患者从PVS中出现。与未经治疗的PVS的通常生存期相比，DBS治疗的PVS病例中有19%（4/21）存活超过10年，这一事实应予以强调。
Twenty-one cases of a persistent vegetative state (PVS) caused by various kinds of brain damage were evaluated neurologically and electrophysiologically at 3 months after the brain injury. The 21 cases were treated by deep brain stimulation (DBS) therapy, and followed up for over 10 years. The stimulation sites were the mesencephalic reticular formation (2 cases) and CM-pf complex (19 cases). Eight of the patients emerged from the PVS, and became able to obey verbal commands. However, they remained in a bedridden state. These 8 cases revealed a desynchronization on continuous EEG frequency analysis. The Vth wave of the ABR and N20 of the SEP could be recorded even with a prolonged latency, and the painrelated P250 was recorded with an amplitude of over 7 µV. The mean survival time of these 8 cases was 6.1 years, as compared to 3.1 years for the other 13 cases. Overall, 4 cases are alive after more than 10 years. DBS therapy may be useful for allowing patients to emerge from a PVS, if the candidates are selected according to neurophysiological criteria. The fact that 19% (4/21) of the PVS cases treated with DBS survived for over 10 years should be stressed in comparison with the usual survival period for the untreated PVS.
Yoichi Katayama：“通过深部脑刺激对持续性植物人状态患者的大脑活动进行表征和修改：与疼痛相关的大脑诱发电位的晚期正向成分”Pace。
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