Diels-Alder cycloaddition approach to puupehenone-related metabolites: Synthesis of the potent angiogenesis inhibitor 8-epipuupehedione
Diels-Alder cycloaddition approach to puupehenone-related metabolites: Synthesis of the potent angiogenesis inhibitor 8-epipuupehedione
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DOI：
10.1021/jo0626663
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发表时间：
2007-04-27
影响因子：
3.6
通讯作者：
Bouanou, H.
中科院分区：
文献类型：
--
作者：
Alvarez-Manzaneda, E. J.;Chahboun, R.;Bouanou, H.
本文介绍了一种基于Diels-Alder环加成法的新合成策略，该策略是由核核醇氧化物合成pupupehenone相关的生物活性代谢物。利用这一方法，合成了海洋对染色质酚和有效的血管生成抑制剂8-表羽己二酮。
A new synthetic strategy toward puupehenone-related bioactive metabolites from sclareol oxide, based on a Diels-Alder cycloaddition approach, is described. Utilizing this, marine ent-chromazonarol and the potent angiogenesis inhibitor 8-epipuupehedione have been synthesized.