VERITAS-Pro: a new measure of adherence to prophylactic regimens in haemophilia
VERITAS-Pro: a new measure of adherence to prophylactic regimens in haemophilia
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DOI：
10.1111/j.1365-2516.2009.02129.x
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发表时间：
2010-03-01
期刊：
影响因子：
3.9
通讯作者：
Shapiro, A.
中科院分区：
文献类型：
--
作者：
Duncan, N.;Kronenberger, W.;Shapiro, A.
建议对重度血友病进行预防性治疗。不遵守预防性治疗方案可能会限制治疗效果并损害结局。本研究的目的是验证一种新的预防性治疗依从性量表，名为经验证的血友病方案治疗依从性量表-预防（VERITAS-Pro），这是一种自我/家长报告问卷，由6个（4项）子量表（时间、剂量、计划、记住、跳过、沟通）的24个问题组成，完成时间约为10分钟，目前仅提供英文版。招募参与者完成VERITAS-Pro进行验证和可靠性分析;招募观察员进行评分者间可靠性分析。验证措施包括参与者和提供者的主观依从性评级以及从输注日志中获得的推荐输注总数。对整个样本以及父母报告和自我报告子样本的数据进行了评价。研究样本包括67例男性，53例（79.1%）诊断为重度FVIII缺乏症。VERITAS-Pro总分和所有分量表的内部一致性为良好至优秀;重测信度相关性非常强。验证措施与VERITAS-Pro评分密切相关。VERITAS-Pro是衡量血友病预防性治疗依从性的可靠有效指标。VERITAS-Pro比全球或非正式的依从性评级具有更大的实用性，因为它代表了从患者角度出发的量化和验证的依从性测量，并将依从性划分为特定区域，从而可以深入了解不依从性的特定问题。该工具可以提高对依从性问题的敏感性，并允许更有针对性的干预以提高依从性。
Prophylactic treatment is recommended for severe haemophilia. Non-adherence to a prophylactic regimen can limit treatment effectiveness and compromise outcomes. The aim of this study is to validate a new prophylactic treatment adherence scale entitled Validated Hemophilia Regimen Treatment Adherence Scale - Prophylaxis (VERITAS-Pro), a self-/parent-report questionnaire consisting of 24 questions on six (four-item) subscales (Time, Dose, Plan, Remember, Skip, Communicate) that takes approximately 10 min to complete and is currently available in English only. Participants were recruited to complete the VERITAS-Pro for validation and reliability analysis; and observers were recruited for inter-rater reliability analysis. Validation measures included subjective adherence ratings from participants and providers and the total number of recommended infusions administered as obtained from infusion logs. Data were evaluated for the entire sample and for parent-report and self-report subsamples. The study sample included 67 males, 53 (79.1%) diagnosed with severe FVIII deficiency. Internal consistency for the total VERITAS-Pro score and all subscales was good to excellent; test-retest reliability correlations were very strong. Validation measures were strongly correlated with VERITAS-Pro scores. The VERITAS-Pro is a reliable and valid measure of adherence to prophylactic treatment of haemophilia. The VERITAS-Pro has greater utility than a global or informal rating of adherence because it represents a quantified and validated measure of adherence from the patient's perspective and it divides adherence into specific areas, allowing insight into particular issues underlying non-adherence. This tool may increase sensitivity to adherence problems and allow more targeted interventions to enhance adherence.