Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours
Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours
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DOI：
10.1136/jcp.2003.10660
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发表时间：
2004-02-01
影响因子：
3.4
通讯作者：
Coletta, PL
中科院分区：
文献类型：
--
作者：
Scott, N;Millward, E;Coletta, PL
目标：为了建立是否胃泌素释放肽（GRP）和GRP受体（GRPR）一起表达在胃肠道类癌tumors.Methods：26类癌肿瘤从胃，小肠，阑尾，结肠直肠进行了研究，通过免疫组化GRP和GRPR.Results：GRP被检测到9 19肿瘤和GRPR在22 26。19例中有6例同时表达配体和受体。GRPR在阑尾和结肠肿瘤中表达较强，而在胃肠道类癌中表达较弱。自分泌/旁分泌途径可能存在GRP刺激的细胞增殖，在这些肿瘤中的一些，类似于小细胞间变性肺癌中所见。
Aims: To establish whether gastrin releasing peptide (GRP) and the GRP receptor (GRPR) are expressed together in gastrointestinal carcinoid tumours.Methods: Twenty six carcinoid tumours from the stomach, small intestine, appendix, and colorectum were investigated by immunohistochemistry for GRP and GRPR.Results: GRP was detected in nine of 19 tumours and GRPR in 22 of 26. Coexpression of both the ligand and receptor was seen in six of 19 cases. GRPR but not GRP was more strongly expressed in appendix and colonic tumours.Conclusions: GRP and GRPR are produced by a large number of gastrointestinal carcinoid tumours. An autocrine/paracrine pathway may exist for GRP stimulated cell proliferation in some of these neoplasms, analogous to that seen in small cell anaplastic carcinoma of the lung.