Eosinophilic Esophagitis
Eosinophilic Esophagitis
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DOI：
10.1016/j.gtc.2008.09.004
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发表时间：
2008-12-01
影响因子：
3.7
通讯作者：
Liacouras, Chris A.
中科院分区：
文献类型：
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作者：
Liacouras, Chris A.
嗜酸性食管炎（EoE）是一种基于临床病理诊断的疾病，涉及食管的局部嗜酸性炎症。在过去的10年里，儿科EoE的诊断显著增加，这不仅是因为胃肠病学家、过敏症专家和病理学家对该疾病的认识更高，也是因为该疾病的发病率增加。EoE的定义是每个高倍视野中存在15个或更多的食管嗜酸性粒细胞，这些嗜酸性粒细胞与对抑酸治疗无反应的临床症状相关。虽然EoE的确切机制尚不清楚，但食物过敏原被认为具有重要作用。有效的治疗选择包括饮食限制和各种类固醇制剂。
Eosinophilic esophagitis (EoE) is a disease based on a clinicopathologic diagnosis that involves a localized eosinophilic inflammation of the esophagus. A significant increase in the diagnosis of pediatric EoE has occurred over the past 10 years not only due to a greater recognition of the disease among gastroenterologists, allergists, and pathologists but also secondary to an increased incidence of the disease. EoE is defined by the presence of 15 or more esophageal eosinophils per high-power field isolated to the esophagus associated with clinical symptoms that do not respond to acid suppression therapy. Although the exact mechanism of EoE is unknown, food allergens are thought to have an important role. Effective treatment options include dietary restrictions and various steroid formulations.