Evoked potential correlates of Post-Traumatic Stress Disorder in refugees with history of exposure to torture
Evoked potential correlates of Post-Traumatic Stress Disorder in refugees with history of exposure to torture
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DOI：
10.1016/j.jpsychires.2013.06.007
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发表时间：
2013-10-01
影响因子：
4.8
通讯作者：
Tancer, Manuel E.
中科院分区：
文献类型：
--
作者：
Gjini, Klevest;Boutros, Nash N.;Tancer, Manuel E.
与创伤后应激障碍（PTSD）相关的信息处理偏差的存在和程度远未得到很好的表征。在这项研究中，我们评估了一组伊拉克难民的听觉和视觉诱发的脑反应，他们暴露于酷刑并发展为PTSD（N = 20），伊拉克难民暴露于类似的创伤，但没有发展为PTSD（N = 20），和年龄，性别和种族匹配的非创伤对照组（N = 20）。我们分别在听觉和视觉感官模式中使用了两种成对刺激范式。我们发现，与对照组相比，PTSD患者的听觉P50和视觉N75反应的幅度显着较小，反映了在信息处理的相对早期阶段（刺激后间隔50-75 ms）对简单感觉输入的反应降低。此外，在这两种模式的早期阶段，对重复刺激的P50/N75反应的抑制不足表明难以过滤掉不相关的感觉输入。在电生理和临床测量之间的关联中，分离评分和P50 S1振幅之间存在显著正相关（p = 0.024），并且更强的听觉P50门控与更高的生活质量指数评分相关（p = 0.013）。此外，较小幅度的N150视觉诱发反应硅显示出较高的回避分数（p = 0.015）的显着关联。本研究的结果强调了早期自动听觉和视觉诱发反应在探索PTSD的信息处理和神经机制方面的重要性。(C)2013爱思唯尔有限公司保留所有权利。
The presence and magnitude of information processing deviations associated with Post-Traumatic Stress Disorder (PTSD) are far from being well-characterized. In this study we assessed the auditory and visually evoked cerebral responses in a group of Iraqi refugees who were exposed to torture and developed PTSD (N = 20), Iraqi refugees who had been exposed to similar trauma but did not develop PTSD (N = 20), and non-traumatized controls matched for age, gender, and ethnicity (N = 20). We utilized two paired-stimulus paradigms in auditory and visual sensory modalities, respectively. We found significantly smaller amplitudes of both the auditory P50 and the visual N75 responses in PTSD patients compared to controls, reflecting decreased response to simple sensory input during a relatively early phase of information processing (interval 50-75 ms post stimulus). In addition, deficient suppression of the P50/N75 response to repeating stimuli at this early stage in both modalities is indicative of difficulty in filtering out irrelevant sensory input. Among associations between electrophysiological and clinical measures, a significant positive correlation was found between dissociation score and P50 S1 amplitudes (p = 0.024), as well as stronger auditory P50 gating correlated with higher quality-of-life index scores (p = 0.013). In addition, smaller amplitudes of N150 visual evoked response to Si showed a significant association with higher avoidance scores (p = 0.015). The results of this study highlight the importance of early automatic auditory and visual evoked responses in probing the information processing and neural mechanisms underlying symptomatology in PTSD. (C) 2013 Elsevier Ltd. All rights reserved.