Electro-acupuncture upregulates CGRP expression after rat spinal cord transection
Electro-acupuncture upregulates CGRP expression after rat spinal cord transection
复制标题
电针上调大鼠脊髓横断后CGRP表达
DOI：
10.1016/j.neuint.2012.10.002
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发表时间：
2012-12-01
影响因子：
4.2
通讯作者：
Zeng, Yuan-Shan
中科院分区：
文献类型：
--
作者：
Li, Wen-Jie;Li, Shu-Min;Zeng, Yuan-Shan
降钙素基因相关肽（CGRP）在神经系统中起着多种重要作用。增加CGRP的表达可以改善受损神经元的存活，防止神经元的丢失。本研究首次在体外研究CGRP对机械损伤的大鼠小脑颗粒神经元（CGNs）的保护作用。然后，我们验证了这一结果，通过外源性管理的CGRP在脊髓完全横断的大鼠。最后，我们观察了电针对大鼠脊髓全横断后CGRP表达的影响。我们发现，无论是在体内还是体外，电针都能提高CGRP的表达，外源性CGRP可能促进损伤神经元的存活。结果提示CGRP可能是GV-EA治疗脊髓损伤时表达的一种特异性神经肽，CGRP对机械损伤神经元的存活具有神经保护作用。(C)2012爱思唯尔有限公司保留所有权利。
Calcitonin gene-related peptide (CGRP) plays a variety of important roles within the nervous system. Increasing CGRP expression could improve the survival of injured neurons and prevent neuronal loss. In this study, we first evaluated in vitro the neuroprotective function of CGRP on mechanically injured cerebellar granule neurons (CGNs) of rats. We then verified this result through exogenous administration of CGRP in a spinal cord transected completely in rats. Finally, we investigated the effect of electro-acupuncture (EA) on CGRP expression following the spinal cord transected completely in rats. We found that EA can improve CGRP expression, and exogenous CGRP may promote the survival of injured neurons, both in vivo and in vitro. Our results suggest that CGRP may be a specific neuropeptide expressed in GV-EA treatment of spinal cord injuries (SCI), and that CGRP may play a neuroprotective role in survival of neurons injured mechanically. (C) 2012 Elsevier Ltd. All rights reserved.