Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila
Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila
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DOI：
10.1126/science.1071124
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发表时间：
2002-05-03
期刊：
影响因子：
56.9
通讯作者：
Rawson, RB
中科院分区：
文献类型：
--
作者：
Dobrosotskaya, IY;Seegmiller, AC;Rawson, RB
动物细胞对其细胞膜的物理和化学性质有精细的控制，但其机制尚不清楚。我们发现，磷脂酰乙醇胺是果蝇体内主要的磷脂，它控制着果蝇细胞膜上固醇调节元件结合蛋白（SREBP）的释放，对脂肪酸和磷脂的合成起到反馈控制作用。研究发现，哺乳动物和果蝇的SREBP加工受不同脂类（分别为甾醇和磷脂酰乙醇胺）的控制，这表明SREBP的基本功能是监测细胞膜组成并相应地调节脂类合成。
Animal cells exert exquisite control over the physical and chemical properties of their membranes, but the mechanisms are obscure. We show that phosphatidylethanolamine, the major phospholipid in Drosophila, controls the release of sterol regulatory element-binding protein (SREBP) from Drosophila cell membranes, exerting feedback control on the synthesis of fatty acids and phospholipids. The finding that SREBP processing is controlled by different lipids in mammals and flies (sterols and phosphatidylethanolamine, respectively) suggests that an essential function of SREBP is to monitor cell membrane composition and to adjust lipid synthesis accordingly.