Dose-related activity of stavudine in patients infected with human immunodeficiency virus.
Dose-related activity of stavudine in patients infected with human immunodeficiency virus.
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司他夫定在人类免疫缺陷病毒感染患者中的剂量相关活性。
DOI：
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发表时间：
1995
影响因子：
6.4
通讯作者：
Lisa M. Dunkle
中科院分区：
文献类型：
--
作者：
Eskild A. Petersen;C. H. Ramírez;W. Hardy;Robert Schwartz;Henry S. Sacks;Stephen E. Follansbee;Dolores M. Peterson;Anne H. Cross;Robert E. Anderson;Lisa M. Dunkle
在一项多中心、随机、开放标签、剂量范围的研究中，为了确定三种剂量水平的司他夫定对感染人类免疫缺陷病毒(HIV)患者的CD4淋巴细胞计数、体重增加和血液学变量的相对影响，152名CD4淋巴细胞计数<lt；或=600/mm3的患者接受了司他夫定0.1 mg/kg/d(n=51)、0.5 mg/kg/d(n=53)或2.0 mg/kg/d(n=48)的治疗。这项研究旨在评估司他夫定在治疗10周后的活性，并允许延长剂量和进行长期安全性随访。外周血单核细胞中CD4淋巴细胞数量的增加和HIV滴度的下降具有明显的剂量效应。司他夫定耐受性良好；唯一与剂量相关的、剂量受限的不良事件是周围神经病变，这通常是可逆的。在这项试验中，最有利的治疗指数是每天0.5毫克/公斤。
In a multicenter, randomized, open-label, dose-ranging study to determine the relative effects of three dose levels of stavudine on CD4 lymphocyte count, weight gain, and hematologic variables in patients infected with human immunodeficiency virus (HIV), 152 patients with CD4 lymphocyte counts < or = 600/mm3 received stavudine at 0.1 mg/kg/day (n = 51), 0.5 mg/kg/day (n = 53), or 2.0 mg/kg/day (n = 48). The study was designed to evaluate the activity of stavudine after 10 weeks of therapy and permitted extended dosing and follow-up for long-term safety. A significant dose effect on increases in CD4 lymphocyte counts and declines in HIV titer in peripheral blood mononuclear cells was observed. Stavudine was well-tolerated; the only dose-related, dose-limiting adverse event was peripheral neuropathy, which usually was reversible. In this trial, the most favorable therapeutic index was seen at 0.5 mg/kg/day.
影响因子：
7.3
作者：
MANSURI, MM;STARRETT, JE;MARTIN, JC
通讯作者：
MARTIN, JC
司他夫定治疗艾滋病和艾滋病相关综合症患者：艾滋病临床试验组 089。
DOI：
10.1093/infdis/171.supplement_2.s123
发表时间：
1995
期刊：
The Journal of infectious diseases
影响因子：
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作者：
Murray,HW;Squires,KE;Weiss,W;Sledz,S;Sacks,HS;Hassett,J;Cross,A;Anderson,RE;Dunkle,LM
通讯作者：
Dunkle,LM
影响因子：
56.9
作者：
LARDER, BA;DARBY, G;RICHMAN, DD
通讯作者：
RICHMAN, DD