DERMAL CYLINDROMA - AN IMMUNOHISTOCHEMICAL STUDY OF 13 CASES
DERMAL CYLINDROMA - AN IMMUNOHISTOCHEMICAL STUDY OF 13 CASES
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DOI：
10.1097/00000372-199506000-00008
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发表时间：
1995-06-01
影响因子：
1.1
通讯作者：
BAPTISTA, AP
中科院分区：
文献类型：
--
作者：
TELLECHEA, O;REIS, JP;BAPTISTA, AP
利用一组抗体对13例皮肤圆柱瘤（DC）的正常外分泌腺和顶泌腺的不同部位进行了染色。 在肿瘤的不同细胞群中发现了不同的染色模式。 虽然细胞角蛋白（CK）19和1/10/11在偶尔的导管结构中的表达可能表明排泄（导管）分化，但α-1-抗胰凝乳蛋白酶、溶菌酶、人乳因子球蛋白1、α平滑肌肌动蛋白（1A 4）以及CK 8和18的表达表明DC和顶浆分泌卷曲之间存在联系。 混合的S-100蛋白，HLA DR和CD 1a阳性细胞的存在证明肿瘤内存在朗格汉斯细胞。 DC与外泌腺和顶泌腺共享上皮膜抗原、癌胚抗原、粘蛋白样癌相关抗原（B12）、层粘连蛋白、胶原IV、纤连蛋白和CD 34（QBEND/10）表达。
Thirteen dermal cylindromas (DC) have been studied immunohistochemically using a panel of antibodies that stain different portions of normal eccrine and apocrine glands. Distinct staining patterns were found in the different cell populations of the tumor. Although the expression of cytokeratins (CK) 19 and 1/10/11 in occasional duct structures could indicate excretory (ductal) differentiation, a link between DC and apocrine secretory coil is suggested by the expression of alpha-1-antichymotrypsin, lysozyme, human milk factor globulin 1, alpha smooth muscle actin (1A4), and CK 8 and 18. The presence of intermingled S-100 protein-, HLA DR-, and CD1a-positive cells argues for the existence of Langerhans cells within the neoplasm. DC shares epithelial membrane antigen, carcinoembryonic antigen, mucin-like carcinoma-associated antigen (B12), laminin, collagen IV, fibronectin, and CD34(QBEND/10) expression with both eccrine and apcrine glands.