IMMUNE-BASED EROSIVE INFLAMMATORY JOINT DISEASE OF THE DOG - CANINE RHEUMATOID-ARTHRITIS .1. CLINICAL, RADIOLOGICAL AND LABORATORY INVESTIGATIONS
IMMUNE-BASED EROSIVE INFLAMMATORY JOINT DISEASE OF THE DOG - CANINE RHEUMATOID-ARTHRITIS .1. CLINICAL, RADIOLOGICAL AND LABORATORY INVESTIGATIONS
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DOI：
10.1111/j.1748-5827.1987.tb01345.x
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发表时间：
1987-09-01
影响因子：
1.6
通讯作者：
BENNETT, D
中科院分区：
文献类型：
--
作者：
BENNETT, D
本文报告了30例犬类风湿性关节炎的特征。这种疾病是一种慢性对称性多关节炎，其特征是关节内的侵蚀性、破坏性变化。后者可以通过X线片上的矿物质损失、不连续的侵蚀或不规则的关节边缘来识别。关节周围软组织增加是常见的，骨膜新生骨并不罕见。最明显的临床特征是全身僵硬，尤其是在休息后。关节经常增厚，操作时疼痛。三分之一的病例除跛行外，还出现发热、嗜睡和食欲不振。滑液评价显示白色细胞数量增加，其中大多数为多晶型;粘蛋白凝块较差。ESR普遍升高，73%的病例中存在类风湿因子（一种抗球蛋白自身抗体）。治疗往往是徒劳的，虽然许多狗可以科普相当长的一段时间。
The features of 30 cases of canine rheumatoid arthritis are described. The disease is a chronic symmetrical polyarthritis characterized by erosive, destructive changes within the joint. The latter can be identified on radiographs by loss of mineral, the presence of discrete erosions or an irregular joint margin. Increased periarticular soft tissue is common and periosteal new bone is not unusual. The most obvious clinical feature is generalized stiffness particularly after rest. Joints are often thickened and painful on manipulation. A third of cases present with pyrexia, lethargy and inappetence in addition to lameness. Synovial fluid evaluation shows an increased number of white cells, most of which are polymorphs; the mucin clot is poor. The ESR is generally increased and rheumatoid factor (an antiglobulin auto-antibody) is present in 73 per cent of cases. Treatment is often unrewarding, although many dogs can cope for considerable periods of time.