Characterisation of NK receptors in guinea-pig urinary bladder smooth muscle: use of selective antagonists.
Characterisation of NK receptors in guinea-pig urinary bladder smooth muscle: use of selective antagonists.
复制标题
豚鼠膀胱平滑肌 NK 受体的表征：选择性拮抗剂的使用。
DOI：
10.1016/0014-2999(92)90834-q
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发表时间：
1992
影响因子：
5
通讯作者：
R. Hill
中科院分区：
文献类型：
--
作者：
J. Longmore;R. Hill
本研究的目的是研究神经激肽受体在介导豚鼠膀胱平滑肌收缩反应中的作用。选择性NK1、NK2和NK3受体激动剂的使用表明，该组织的收缩反应是通过激活NK1和NK2介导的，而不是通过激活NK3受体。NK1受体拮抗剂(±)-CP 96,345可抑制P物质对[Sar9，Met(02)11]物质的反应，而NK2受体拮抗剂L-659,877可抑制肾上腺素的反应(NK2受体脱敏后)。
The aim of the present study was to characterise the neurokinin receptors involved in mediating contractile responses in guinea-pig urinary bladder smooth muscle. The use of selective NK1, NK2, and NK3receptor agonists indicated that contractile responses in this tissue are mediated via activation of NK1and NK2, but not NK3receptors. This was confirmed by the observation that responses to [Sar9,Met(02)11]substance P were inhibited by (±)-CP 96,345 (a NK1receptor antagonist) and responses to eledoisin (following NK2receptor desensitization) were inhibited by L-659,877 (a NK2receptor antagonist).