Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 2: Human papillomavirus associated oral and oropharyngeal squamous cell carcinoma.
Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 2: Human papillomavirus associated oral and oropharyngeal squamous cell carcinoma.
复制标题
DOI：
10.1186/1746-160x-6-15
复制
发表时间：
2010-07-15
影响因子：
3
通讯作者：
Lemmer J
中科院分区：
文献类型：
--
作者：
Feller L;Wood NH;Khammissa RA;Lemmer J
口腔和口咽部的人乳头瘤病毒（HPV）感染可以通过各种性传播和社会传播形式获得。HPV-16基因型存在于许多口腔和口咽鳞状细胞癌中。它在口咽鳞状细胞癌的发生中具有重要的病因学作用，这些受试者通常更年轻，更倾向于高风险性行为，具有更高的HPV-16血清抗体滴度，使用更少的烟草，并且比HPV细胞阴性口咽鳞状细胞癌受试者具有更好的生存率。在这部分受试者中，HPV阳性癌细胞具有独特的分子特征。与HPV阳性的口咽鳞状细胞癌相比，HPV-16和其他高危型HPV基因型与口腔粘膜鳞状细胞癌之间的因果关系较弱，这种关联的性质尚不清楚。在性活动开始前常规接种针对高危型HPV基因型的HPV疫苗可能会降低HPV介导的口腔和口咽鳞状细胞癌的发病率。本文着重于HPV感染的口腔和口咽部，强调HPV和鳞状细胞癌之间的联系，并在确定HPV与口腔和口咽部鳞状细胞癌的因果关系的可用诊断测试的局限性。
Human papillomavirus (HPV) infection of the mouth and oropharynx can be acquired by a variety of sexual and social forms of transmission. HPV-16 genotype is present in many oral and oropharyngeal squamous cell carcinomata. It has an essential aetiologic role in the development of oropharyngeal squamous cell carcinoma in a subset of subjects who are typically younger, are more engaged with high-risk sexual behaviour, have higher HPV-16 serum antibody titer, use less tobacco and have better survival rates than in subjects with HPV-cytonegative oropharyngeal squamous cell carcinoma. In this subset of subjects the HPV-cytopositive carcinomatous cells have a distinct molecular profile. In contrast to HPV-cytopositive oropharyngeal squamous cell carcinoma, the causal association between HPV-16 and other high-risk HPV genotypes and squamous cell carcinoma of the oral mucosa is weak, and the nature of the association is unclear. It is likely that routine administration of HPV vaccination against high-risk HPV genotypes before the start of sexual activity will bring about a reduction in the incidence of HPV-mediated oral and oropharyngeal squamous cell carcinoma. This article focuses on aspects of HPV infection of the mouth and the oropharynx with emphasis on the link between HPV and squamous cell carcinoma, and on the limitations of the available diagnostic tests in identifying a cause-and-effect relationship of HPV with squamous cell carcinoma of the mouth and oropharynx.