GLIAL-CELL DIVERSIFICATION IN THE RAT OPTIC-NERVE
GLIAL-CELL DIVERSIFICATION IN THE RAT OPTIC-NERVE
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DOI：
10.1126/science.2648568
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发表时间：
1989-03-17
期刊：
影响因子：
56.9
通讯作者：
RAFF, MC
中科院分区：
文献类型：
--
作者：
RAFF, MC
发育神经生物学的一个核心挑战是了解早期哺乳动物胚胎中表面上同质的神经上皮细胞群体是如何导致成熟中枢神经系统中神经细胞(神经元)和支持细胞(神经胶质细胞)的巨大多样性的。由于视神经是中枢神经系统中最简单的部分之一，含有几种类型的胶质细胞，但没有内在神经元，因此是研究神经上皮细胞如何多样化的一个有吸引力的地方。对培养的大鼠视神经细胞发育的研究表明，细胞间的相互作用和固有的细胞程序在胶质细胞多样化中发挥着重要作用。
A central challenge in developmental neurobiology is to understand how an apparently homogeneous population of neuroepithelial cells in the early mammalian embryo gives rise to the great diversity of nerve cells (neurons) and supporting cells (glial cells) in the mature central nervous system. Because the optic nerve is one of the simplest parts of the central nervous system, containing several types of glial cells but no intrinsic neurons, it is an attractive place to investigate how neuroepithelial cells diversify. Studies of developing rat optic nerve cells in culture suggest that both cell-cell interactions and intrinsic cellular programs play important parts in glial cell diversification.