Multiple Systemic Vascular Risk Factors Are Associated With Low-Tension Glaucoma.
Multiple Systemic Vascular Risk Factors Are Associated With Low-Tension Glaucoma.
复制标题
DOI：
10.1097/ijg.0000000000001964
复制
发表时间：
2022-01-01
影响因子：
2
通讯作者：
中科院分区：
文献类型：
--
作者：
多种全身性血管相关疾病，包括全身性高血压和低血压、糖尿病、偏头痛、外周血管疾病、雷诺综合征和贫血与低眼压性青光眼相关。本研究的目的是确定与低眼压性青光眼相关的系统性危险因素。采用回顾性病例对照研究设计，以确定2005年至2015年期间在马约诊所眼科就诊的低眼压性青光眼患者以及年龄匹配和性别匹配的对照组，每组包含277例患者。低眼压性青光眼组有更多的近视屈光不正（-1.6 vs.-1.0 D，P < 0.001），更低的眼内压（14.2 vs. 15.2 mm Hg，P < 0.001），更高的杯盘比（0.7 vs. 0.3，P < 0.001）。低眼压性青光眼组肥胖的可能性明显较低（体重指数> 30，P = 0.03）。该组的全身性高血压患病率显著较高[比值比（OR）：1.64，P = 0.004]，糖尿病（OR：3.01，P < 0.001），外周血管疾病（OR：2.61，P = 0.009），偏头痛（OR值：2.12，P = 0.02），贫血（OR：2.18，P = 0.003），全身性低血压（OR：4.43，P < 0.001），雷诺氏综合征（OR：3.09，P = 0.05），血管紧张素转换酶抑制剂（OR：1.64，P = 0.01）或钙通道阻滞剂（OR：1.98，P = 0.004）。校正全身性高血压后，钙通道阻滞剂的使用仍显着（OR：1.70，P = 0.03）。在高脂血症、阻塞性睡眠呼吸暂停、冠状动脉疾病、颈动脉狭窄、卒中或他汀类药物、血管紧张素转换酶抑制剂、血管紧张素受体阻滞剂、β受体阻滞剂或二甲双胍使用方面，两组间无显著差异。多种血管相关疾病与低眼压性青光眼相关，包括全身性高血压、糖尿病、外周血管疾病、偏头痛、雷诺综合征、贫血、全身性低血压和钙通道阻滞剂使用。这项研究加强了低眼压性青光眼血管假说的证据。
Multiple systemic vascular-associated conditions including systemic hypertension and hypotension, diabetes mellitus, migraine headache, peripheral vascular disease, Raynaud syndrome, and anemia were associated with low-tension glaucoma. The purpose of this study was to identify systemic risk factors associated with low-tension glaucoma. A retrospective case-control study design was employed to identify patients seen at the Mayo Clinic Department of Ophthalmology between 2005 and 2015 with low-tension glaucoma and an age-matched and sex-matched control group, each containing 277 patients. The low-tension glaucoma group had more myopic refractive errors (−1.6 vs. −1.0 D, P < 0.001), lower intraocular pressure (14.2 vs. 15.2 mm Hg, P < 0.001), and a higher cup-to-disc ratio (0.7 vs. 0.3, P < 0.001). The low-tension glaucoma group was significantly less likely to be obese (body mass index > 30, P = 0.03). This group had a significantly higher prevalence of systemic hypertension [odds ratio (OR): 1.64, P = 0.004], diabetes mellitus (OR: 3.01, P < 0.001), peripheral vascular disease (OR: 2.61, P = 0.009), migraine headache (OR: 2.12, P = 0.02), anemia (OR: 2.18, P = 0.003), systemic hypotension (OR: 4.43, P < 0.001), Raynaud syndrome (OR: 3.09, P = 0.05), and angiotensin-converting enzyme inhibitor (OR: 1.64, P = 0.01) or calcium channel blocker use (OR: 1.98, P = 0.004). After adjusting for systemic hypertension, calcium channel blocker use remained significant (OR: 1.70, P = 0.03). No significant difference was found between groups with respect to hyperlipidemia, obstructive sleep apnea, coronary artery disease, carotid stenosis, stroke, or statin, angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, beta-blocker, or metformin use. Multiple vascular-associated conditions were associated with low-tension glaucoma including systemic hypertension, diabetes mellitus, peripheral vascular disease, migraine headache, Raynaud syndrome, anemia, systemic hypotension, and calcium channel blocker use. This study strengthens the evidence for the vascular hypothesis of low-tension glaucoma.