Influence of the Circadian System on Disease Severity.
Influence of the Circadian System on Disease Severity.
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DOI：
10.1016/j.jsmc.2009.02.005
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发表时间：
2009-06-01
影响因子：
2.8
通讯作者：
Shea, Steven A
中科院分区：
文献类型：
--
作者：
Litinski, Mikhail;Scheer, Frank Ajl;Shea, Steven A
许多疾病的严重程度不同于白天和黑夜。例如，心血管不良事件在早上达到高峰，哮喘往往在晚上恶化，颞叶癫痫发作在下午最常见。这些模式可能是由于环境和行为的昼夜节律，和/或生理的内源性昼夜节律。此外，内源性昼夜节律系统和行为周期之间的长期不一致可能是倒班工人患糖尿病、肥胖症、心血管疾病和某些癌症风险增加的原因。在这里，我们描述了疾病严重程度和昼夜节律/行为失调的这种日常变化的规模、相关性和潜在的生物学基础，并介绍了这些见解如何有助于开发适当的计时疗法。
The severity of many diseases varies across the day and night. For example, adverse cardiovascular incidents peak in the morning, asthma is often worse at night and temporal lobe epileptic seizures are most prevalent in the afternoon. These patterns may be due to the day/night rhythm in environment and behavior, and/or endogenous circadian rhythms in physiology. Furthermore, chronic misalignment between the endogenous circadian timing system and the behavioral cycles could be a cause of increased risk of diabetes, obesity, cardiovascular disease and certain cancers in shift workers. Here we describe the magnitude, relevance and potential biological basis of such daily changes in disease severity and of circadian/behavioral misalignment, and present how these insights may help in the development of appropriate chronotherapy.