Depression of muscle spindle activity--a new type of pharmacological action?
Depression of muscle spindle activity--a new type of pharmacological action?
复制标题
抑制肌梭活动——一种新型药理作用？
DOI：
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发表时间：
1962
期刊：
影响因子：
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通讯作者：
H.‐U. Fehr
中科院分区：
文献类型：
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作者：
H. Bein;H.‐U. Fehr
本文观察了静脉注射2，4-di(diethylamino)-6-(2-phenylacetylhydrazino)-1，3，5-triazine(汽巴28882-BA)对麻醉猫胫骨前肌和趾长伸肌去传出肌梭活动和去大脑猫γ运动神经元活动的影响。该药抑制肌梭的静态活动和伽马运动神经元的自发活动。相反，肌梭对快速拉伸的反应没有受到影响。28882-BA对肌梭活动的影响类似于肌肉的渐进性卸载或缩短。28882-BA拮抗琥珀胆碱对肌梭的兴奋作用。28882-BA对伽马运动神经元对不同驱动刺激反应的影响是不可预测的。
The effect of 2,4-di(diethylamino)-6-(2-phenylacetylhydrazino)-1,3,5-triazine (Ciba 28882-Ba) injected intravenously on the activity of de-efferented muscle spindles of the tibialis anterior and extensor digitorum longus muscles of anaesthetized cats, and on gamma-motoneurones of decerebrate cats, was investigated. The drug depressed both the static activity of muscle spindles and the spontaneous activity of gamma-motoneurones. In contrast, the response of muscle spindles to rapid stretch was not affected. The effect of 28882-Ba on the activity of the muscle spindles resembled that of progressive unloading or shortening of the muscle. 28882-Ba antagonized excitation of the muscle spindle by suxamethonium. The effect of 28882-Ba on the response of the gamma-motoneurones to various driving stimuli was not predictable.