Evaluation of abdominal fat distribution in noninsulin-dependent diabetes mellitus: Relationship to insulin resistance
Evaluation of abdominal fat distribution in noninsulin-dependent diabetes mellitus: Relationship to insulin resistance
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DOI：
10.1210/jc.83.4.1306
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发表时间：
1998-04-01
影响因子：
5.8
通讯作者：
Cathelineau, G
中科院分区：
文献类型：
--
作者：
Gautier, JF;Mourier, A;Cathelineau, G
内脏脂肪组织的积聚与代谢并发症有关，如非胰岛素依赖型糖尿病。本研究的目的是评价腹部脂肪组织对非胰岛素依赖型糖尿病(NIDDM)患者胰岛素敏感性的影响。根据21例男性NIDDM患者脐部水平的轴位磁共振图像计算腹部脂肪面积[年龄45.6±8.3(+/-SD)岁；体重指数29.3+/-4.5 kg/m(-2)；全身脂肪(皮脂厚度)26.8+/-5.4%；腰臀比0.97+/-0.07；糖尿病病程59+/-47个月；血红蛋白A(1c)，8.1+/-1.5%]。通过胰岛素耐量试验评价胰岛素敏感性。腹深脂肪面积为135.3±55.1cm2，sc腹脂面积为211.8±99.1 cm(2)。血糖消失率为2.11+/-0.87%/分，与腹脂呈负相关(r=0.72，P=0.0025)。相比之下，sc腹脂面积、全身脂肪、体重指数和腰臀比与血糖消失率无关。血浆甘油三酯浓度平均为1.80+/-0.8mmol.L，与腹脂呈正相关(r=0.69，P=0.0018)。我们得出结论，胰岛素敏感性与内脏脂肪组织堆积NIDDM密切相关。
Accumulation of visceral adipose tissue is associated with metabolic complications such as noninsulin-dependent diabetes mellitus. The aim of this study was to evaluate the effect of abdominal adipose tissue on insulin sensitivity in subjects with noninsulin-dependent diabetes mellitus (NIDDM). Areas of abdominal fat were calculated from axial magnetic resonance images obtained at the level of the umbilicus in 21 men with NIDDM [age, 45.6+/-8.3 (+/-SD) yr; body mass index, 29.3+/-4.5 kg/m(-2); total body fat (skinfold thickness), 26.8+/-5.4%; waist to hip ratio, 0.97+/-0.07; duration of diabetes, 59+/-47 months; hemoglobin A(1c), 8.1+/-1.5%]. Insulin sensitivity was evaluated by an insulin tolerance test. The areas of deep abdominal fat and sc abdominal fat were, respectively, 135.3+/-55.1 and 211.8+/-99.1 cm(2). The blood glucose disappearance rate was 2.11+/-0.87%/min and was negatively related to deep abdominal fat (r = 0.72; P = 0.0025). In contrast, areas of sc abdominal fat, total body fat, body mass index, and waist to hip ratio were not related to the blood glucose disappearance rate. Plasma triglyceride concentrations averaged 1.8+/-0.8 mmol/L and were positively related to deep abdominal fat (r = 0.69; P = 0.0018). We conclude that insulin sensitivity is strongly related to visceral adipose tissue accumulation NIDDM.