A molecular propeller effect for chiral separation and analysis.
A molecular propeller effect for chiral separation and analysis.
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DOI：
10.1038/ncomms8868
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发表时间：
2015-07-28
影响因子：
16.6
通讯作者：
Chachisvilis M
中科院分区：
文献类型：
--
作者：
Clemens JB;Kibar O;Chachisvilis M
对映异构体具有几乎相同的物理性质，但具有不同的手性几何形状，使其难以识别和分离。在这里，我们表明，当暴露于旋转电场，左手和右手的手性分子旋转的领域和微观螺旋桨;此外，由于他们的相反的手，他们推动沿着轴的领域旋转相反的方向。我们引入了一个新的分子参数称为流体动力学手性表征耦合的旋转运动的手性分子到其平移运动和量化的方向和速度这样的运动。我们证明了在不使用手性选择剂或圆偏振光的情况下，溶液中对应物对映体的富集水平>80%。我们希望我们的研究结果对药物发现，分析和手性化学，包括绝对构型的测定，以及影响人工和天然分子系统的理解，其中涉及分子的旋转运动产生影响。 对映异构体的分离和分析是一项困难的任务，因为它们通常显示相同的物理性质。在这里，作者展示了具有非零偶极子的手性分子如何在旋转电场的影响下被推向相反的方向。
Enantiomers share nearly identical physical properties but have different chiral geometries, making their identification and separation difficult. Here we show that when exposed to a rotating electric field, the left- and right-handed chiral molecules rotate with the field and act as microscopic propellers; moreover, owing to their opposite handedness, they propel along the axis of field rotation in opposite directions. We introduce a new molecular parameter called hydrodynamic chirality to characterize the coupling of rotational motion of a chiral molecule into its translational motion and quantify the direction and velocity of such motion. We demonstrate >80% enrichment level of counterpart enantiomers in solution without using chiral selectors or circularly polarized light. We expect our results to have an impact on multiple applications in drug discovery, analytical and chiral chemistry, including determination of absolute configuration, as well as in influencing the understanding of artificial and natural molecular systems where rotational motion of the molecules is involved. Separation and analysis of enantiomers is a difficult task due to the normally identical physical properties they display. Here, the authors show how chiral molecules with non-zero dipoles can be propelled in opposite directions under the influence of a rotating electric field.