Cardiovascular risk factors among patients with chronic kidney disease attending a tertiary hospital in Uganda.
Cardiovascular risk factors among patients with chronic kidney disease attending a tertiary hospital in Uganda.
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DOI：
10.5830/cvja-2015-045
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发表时间：
2015-07
影响因子：
0.7
通讯作者：
Mondo CK
中科院分区：
文献类型：
--
作者：
Babua C;Kalyesubula R;Okello E;Kakande B;Sebatta E;Mungoma M;Mondo CK
慢性肾脏病（CKD）是心血管疾病发生的危险因素，是 CKD 患者发病和死亡的主要原因。关于 CKD 患者心血管危险因素的当地数据普遍很少。旨在确定乌干达穆拉戈国家转诊医院肾脏病门诊就诊的 CKD 患者中常见心血管危险因素的患病率。这是一项横断面研究，招募了 217 名平均年龄为 43 岁的患者，历时 9 个月。使用标准化问卷收集有关人口特征、心血管疾病危险因素、全血细胞计数、肾功能测试/电解质和血脂谱的数据。 111 名（51.2%）参与者为男性。 90% 的参与者报告有高血压，而 11.5% 的参与者有吸烟史。 22 名参与者 (10.2%) 肥胖，16.1% 患有糖尿病。总共 71.9% 的人血红蛋白浓度 < 11 g/dl，贫血患病率随着肾功能衰竭的进展而增加 (p < 0.001)； 44.7% 患有低钙血症，39.2% 患有高磷酸血症。研究发现，钙和磷酸盐水平异常的患病率随着肾功能的下降而增加（钙的 p = 0.004，磷酸盐的 p < 0.001）。这项研究表明，传统和非传统心血管危险因素在穆拉戈医院肾病门诊就诊的 CKD 患者中频繁发生。
Chronic kidney disease (CKD) is a risk factor for the development of cardiovascular disease, which is the primary cause of morbidity and mortality in patients with CKD. Local data about cardiovascular risk factors among CKD patients is generally scanty. To determine the prevalence of the common cardiovascular risk factors among patients with CKD attending the nephrology out-patient clinic in Mulago national referral hospital in Uganda. This was a cross-sectional study in which 217 patients with a mean age of 43 years were recruited over a period of nine months. Data on demographic characteristics, risk factors for cardiovascular disease, complete blood count, renal function tests/electrolytes, and lipid profiles were collected using a standardised questionnaire. One hundred and eleven (51.2%) of the participants were male. Hypertension was reported in 90% of participants while cigarette smoking was present in 11.5%. Twenty-two participants (10.2%) were obese and 16.1% were diabetic. A total of 71.9% had a haemoglobin concentration < 11 g/dl, with the prevalence of anaemia increasing with advancing renal failure (p < 0.001); 44.7% were hypocalcaemic and 39.2% had hyperphosphataemia. The prevalence of abnormal calcium and phosphate levels was found to increase with declining renal function (p = 0.004 for calcium and p < 0.001 for phosphate). This study demonstrated that both traditional and non-traditional cardiovascular risk factors occurred frequently in patients with CKD attending the nephrology out-patient clinic at Mulago Hospital.