Photodynamic therapy with meta-tetrahydroxyphenylchlorin (Foscano®) in the management of squamous cell carcinoma of the head and neck: experience with 35 patients
Photodynamic therapy with meta-tetrahydroxyphenylchlorin (Foscano®) in the management of squamous cell carcinoma of the head and neck: experience with 35 patients
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DOI：
10.1007/s00405-009-0947-2
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发表时间：
2009-12-01
影响因子：
2.6
通讯作者：
Maier, Heinz
中科院分区：
文献类型：
--
作者：
Lorenz, Kai Johannes;Maier, Heinz
光动力疗法（PDT）是一种相对较新的治疗皮肤和粘膜浅表性肿瘤的方法。注射光敏剂后，肿瘤区域暴露在非热激光下。这会引起光毒性反应，产生破坏肿瘤细胞的氧自由基。2003年11月至2007年7月，共有35名患有复发性鳞状细胞癌或头颈部继发性肿瘤的患者在乌尔姆的德国武装部队医院接受了PDT治疗。这些病人要么失败了，要么发现不适合接受其他治疗。间置四羟基苯基氯（mTHPC），商品名为Foscan (R)，被用作光敏剂。21例患者（60%）局部控制，10例患者（28.5%）部分缓解。4例患者（11.5%）对PDT治疗无反应。平均总生存期为401.45（+/- 321.2）天，治疗结束后中位生存期为356天。平均无复发生存期为327.7（±131.1）天，完全缓解患者的中位生存期为181天。所有患者均未出现严重并发症。光动力疗法是一种重要的治疗选择，对于复发性癌或上消化道继发性肿瘤患者，谁已经失败或不适合其他治疗。由于目前已取得的良好的治疗效果，PDT在未来也可能在口腔、咽、喉浅表性肿瘤的初级治疗中发挥作用。
Photodynamic therapy (PDT) is a relatively new method of treating superficial tumours of the skin and mucosa. After the injection of a photosensitising agent, the tumour area is exposed to non-thermal laser light. This causes a phototoxic reaction, producing oxygen radicals that destroy tumour cells. From November 2003 to July 2007, a total of 35 patients with recurrent squamous cell carcinoma or secondary tumours of the head and neck region were treated with PDT at the German Armed Forces Hospital in Ulm. These patients had failed or found unsuitable for other treatments. Meta-tetrahydroxyphenylchlorin (mTHPC), known under the trade name of Foscan (R), was used as the photosensitising agent. Local control was achieved in 21 patients (60%) and partial remission in 10 patients (28.5%). Four patients (11.5%) did not respond to PDT treatment. The mean duration of overall survival was 401.45 (+/- 321.2) days, median was 356 after the completion of treatment. The mean duration of recurrence-free Survival was 327.7 (+/- 131.1) days, median was 181 for patients with complete remission. None of the patient developed serious complications. Photodynamic therapy is an important treatment option for patients who present with recurrent carcinoma or secondary tumours of the upper aerodigestive tract and who have failed or unsuitable for other treatments. Due to the excellent treatment results that have been achieved so far, PDT may in the future also play a role in the primary treatment Of Superficial tumours of the oral cavity, pharynx and larynx.