Cofactors for the acquisition of HIV-1 among heterosexual men: prospective cohort study of trucking company workers in Kenya
Cofactors for the acquisition of HIV-1 among heterosexual men: prospective cohort study of trucking company workers in Kenya
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DOI：
10.1097/00002030-199904010-00010
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发表时间：
1999-04-01
期刊：
影响因子：
3.8
通讯作者：
Kreiss, L
中科院分区：
文献类型：
--
作者：
Rakwar, J;Lavreys, L;Kreiss, L
目的：确定HIV-1感染在东非货运公司员工队列中的流行率、发病率和相关因素。方法：将HIV-1血清阴性的货运公司员工纳入一项前瞻性队列研究，每隔3个月对HIV-1血清转化、性传播疾病和性行为进行评估。结果：1500名货车运输公司员工HIV-1基线血清阳性率为17.8%。在752名HIV-1血清阴性男性中，HIV-1年血清发病率为3.1%。在单变量分析中，HIV-1感染与以下因素相关：年龄在25岁以下、性行为10年或以下、职业为司机/司机助理、每月职业旅行超过14天、非基督教或穆斯林宗教、未割包皮、与妓女发生性行为、与女友/随意性伴侣发生性行为、婚外性行为、梅毒螺旋体、ducreyi嗜血杆菌、单纯疱疹病毒2型（P值均小于或等于0.05）。通过多变量分析，HIV-1感染与以下因素独立相关：10年或更少的性行为（危险率比（HRR） 2.0, 95%可信区间（CI） 1.0-4.3）、作为司机/司机助理的职业（HRR 3.9, 95% CI 1.7-9.0）、基督教或穆斯林以外的宗教（HRR 6.1, 95% CI 1.4-25.7）、未割包膜状态（HRR 2.3, 95% CI 1.0-5.0）以及与妓女发生无保护的性行为（HRR 2.8, 95% CI 1.1-7.0）。结论：卡车运输公司员工在入组时HIV-1血清阳性率高，随访期间HIV-1血清发病率高。HIV-1血清转化的危险因素包括性活动年数、职业、宗教、未割包皮状态以及与妓女发生无保护的性行为。这一人群是HIV-1预防试验和行为干预的适当目标人群。(C) 1999 Lippincott Williams & Wilkins。
Objective: To determine the prevalence, incidence, and correlates of HIV-1 infection in a cohort of east African trucking company employees.Methods: HIV-1-seronegative trucking company employees were enrolled in a prospective cohort study and evaluated at 3 monthly intervals for HIV-1 seroconversion, sexually transmitted diseases, and sexual behavior.Results: The baseline seroprevalence of HIV-1 among 1500 trucking company employees was 17.8%. Among 752 HIV-1-seronegative men who were followed, the HIV-1 annual seroincidence was 3.1%. In univariate analysis, HIV-1 acquisition was associated with age under 25 years, 10 years or less of sexual activity, occupation as a driver/driver's assistant, occupational travel for more than 14 days per month, religion other than Christian or Muslim, uncircumcised status, sex with a prostitute, sex with a girlfriend/casual partner, extramarital sex, and enrollment seropositivity to Treponema pallidum, Haemophilus ducreyi, and Herpes simplex virus type 2 (all P values less than or equal to 0.05). Using multivariate analysis, HIV-1 acquisition was independently associated with 10 years or less of sexual activity (hazard rate ratio (HRR) 2.0, 95% confidence interval (CI) 1.0-4.3), occupation as a driver/driver's assistant (HRR 3.9, 95% CI 1.7-9.0), religion other than Christian or Muslim (HRR 6.1, 95% CI 1.4-25.7), uncircumcised status (HRR 2.3, 95% CI 1.0-5.0), and unprotected sex with a prostitute (HRR 2.8, 95% CI 1.1-7.0).Conclusions: Trucking company employees had a high HIV-1 seroprevalence rate at enrollment and a high HIV-1 seroincidence during follow-up. Risk Factors for HIV-1 seroconversion included years of sexual activity, occupation, religion, uncircumcised status, and unprotected sex with a prostitute. This population is an appropriate target for HIV-1 prevention trials and behavioral interventions. (C) 1999 Lippincott Williams & Wilkins.