Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode
Colorimetric Calcium Probe with Comparison to an Ion-Selective Optode
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DOI：
10.1021/acsomega.8b01813
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发表时间：
2018-10
期刊：
影响因子：
4.1
通讯作者：
Changyou Zhu;Manling Huang;Jialing Lan;L. Chung;Xin Li;Xiaojiang Xie
中科院分区：
文献类型：
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作者：
Changyou Zhu;Manling Huang;Jialing Lan;L. Chung;Xin Li;Xiaojiang Xie
小分子探针的设计策略为许多合成化学传感器奠定了基础。本文提出了一种受离子载体离子选择性光电探针启发的水溶性比色钙分子探针，其检测范围可调（在pH 7时约为微摩尔）。Ca2+的结合导致探针的去质子化，从而产生显著的光谱变化，模拟了离子选择光电器件中的离子交换过程。Ca2+和H+的1:1交换被Job的情节所证实。计算研究揭示了可能的探针- ca2 +复合物的单体和二聚体形式。
Design strategies for small molecular probes lay the foundation of numerous synthetic chemosensors. A water-soluble colorimetric calcium molecular probe inspired by the ionophore-based ion-selective optode is presented here with a tunable detection range (around micromolar at pH 7). The binding of Ca2+ resulted in the deprotonation of the probe and thus a significant spectral change, mimicking the ion-exchange process in ion-selective optodes. The 1:1 exchange between Ca2+ and H+ was confirmed with Job’s plot. Computational studies revealed possible monomer and dimer forms of the probe–Ca2+ complexes.