Manipulating the anabolic and catabolic response in bone graft remodeling:: Synergism by a combination of local BMP-7 and a single systemic dosis of zoledronate
Manipulating the anabolic and catabolic response in bone graft remodeling:: Synergism by a combination of local BMP-7 and a single systemic dosis of zoledronate
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DOI：
10.1002/jor.20625
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发表时间：
2008-09-01
影响因子：
2.8
通讯作者：
Tagil, Magnus
中科院分区：
文献类型：
--
作者：
Harding, Anna Kajsa;Aspenberg, Per;Tagil, Magnus
骨移植物的重塑可以受到合成代谢物质（例如形态发生蛋白（BMP））和抗分解代谢物质（例如双膦酸盐）的影响。 BMP 是有效的骨合成代谢物质，但也能促进分解代谢并引起骨吸收。双膦酸盐抑制破骨细胞功能，可用于推迟骨吸收。在本研究中，在大鼠骨室模型中探索了两种药物的组合。松质骨移植物用 BMP-7 或盐水处理，并放置在植入近端胫骨的骨室中。 2周后，皮下注射0.1 mg/kg唑来膦酸或生理盐水。 6周后处死大鼠，通过组织形态计量学测量骨向移植物的长入距离和移植物的吸收。 BMP-7 显着（p = 0.007）增加了新骨向移植物内生长的距离，从对照组的 2.0 毫米（SD = 0.98 毫米）增加到 3.1 毫米（SD = 0.93 分钟）。如果不给予双磷酸盐，大部分新形成的和旧的移植骨会被吸收。单次注射唑来膦酸显着（p
Remodeling of a bone p raft can be influenced both by anabolic substances, such as a ban e morphogenic protein (BMP) and by anticatabolic substances, such as the bisphosphonates. BMPs are potent bone anabolic substances, but also boost catabolism and cause resorption. Bisphosphonates inhibit osteoclast function and can be used to postpone resorption. In the present study a combination of both drugs was explored in a rat bone chamber model. Cancellous bone grafts were treated with either BMP-7 or saline and placed in a bone chamber implanted in the proximal tibia. After 2 weeks, an injection of either zoledronate 0.1 mg/kg or saline was given subcutaneously. The rats were killed after 6 weeks, and bone ingrowth distance into the graft and graft resorption were measured by histomorphometry. BMP-7 significantly (p = 0.007) increased new bone ingrowth distance into the graft from 2.0 mm (SD = 0.98 mm) in the controls to 3.1 mm (SD = 0.93 min). If bisphosphonate was not given, most of the newly formed and old graft bone was resorbed. A single injection of zoledronate significantly (p