Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus
Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus
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DOI：
10.4049/jimmunol.167.4.2361
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发表时间：
2001-08-15
影响因子：
4.4
通讯作者：
Pascual, V
中科院分区：
文献类型：
--
作者：
Arce, E;Jackson, DG;Pascual, V
我们分析了儿童系统性红斑狼疮（SLE）和健康对照组的血液B细胞亚群。我们发现正常循环的成熟B细胞库由四个亚群组成：传统的幼稚和记忆B细胞，一个新的B细胞亚群，具有孕激素中心表型（IgD（+）CD 38（+）centerin（+）），和一个浆细胞前体亚群（CD 20（-）CD 19（+/low）CD 27（+/++）CD 38（++））。在SLE患者中，初始和记忆B细胞（CD 20（+）CD 38（-））减少了90%，而寡克隆浆细胞前体细胞扩增了3倍，与疾病活动和治疗方式无关。SLE中的孕前期中心细胞比常规B细胞减少的程度更小，因此在许多患者中代表主要的血液B细胞亚群。因此，SLE与主要的血液B细胞亚群改变有关。
We have analyzed the blood B cell subpopulations of children with systemic lupus erythematosus (SLE) and healthy controls. We found that the normal recirculating mature B cell pool is composed of four subsets: conventional naive and memory B cells, a novel B cell subset with pregerminal center phenotype (IgD(+)CD38(+)centerin(+)), and a plasma cell precursor subset (CD20(-)CD19(+/low)CD27(+/++) CD38(++)). In SLE patients, naive and memory B cells (CD20(+)CD38(-)) are similar to 90% reduced, whereas oligoclonal plasma cell precursors are 3-fold expanded, independently of disease activity and modality of therapy. Pregerminal center cells in SLE are decreased to a lesser extent than conventional B cells, and therefore represent the predominant blood B cell subset in a number of patients. Thus, SLE is associated with major blood B cell subset alterations.