The utility and risks of therapeutic nanotechnology in the retina.
The utility and risks of therapeutic nanotechnology in the retina.
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DOI：
10.1177/25158414211003381
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发表时间：
2021-01
影响因子：
2.5
通讯作者：
Hajrasouliha AR
中科院分区：
文献类型：
--
作者：
Scheive M;Yazdani S;Hajrasouliha AR
纳米技术在医学中的临床应用在不久的将来有望用于治疗，诊断和手术改进。纳米眼科学中的纳米技术正处于临床应用的早期阶段，包括针对眼部疾病，特别是视网膜病的眼部药物和基因递送系统。视网膜疾病的治疗具有挑战性，因为目前的干预措施，如玻璃体内注射，受到其侵入性的限制。这篇评论探讨了纳米技术的方法，视网膜疾病的临床背景。纳米技术有可能通过克服限制进入视网膜的保护性解剖学和生理学屏障所造成的限制来改变药理学和外科手术干预。纳米颗粒在诊断学中应用的临床前研究表明，纳米颗粒可以增强现有的诊断和筛查工具，更早更容易地检测疾病，并提高疾病进展监测的精度。
The clinical application of nanotechnology in medicine is promising for therapeutic, diagnostic, and surgical improvements in the near future. Nanotechnologies in nano-ophthalmology are in the early stages of application in clinical contexts, including ocular drug and gene delivery systems addressing eye disorders, particularly retinopathies. Retinal diseases are challenging to treat as current interventions, such as intravitreal injections, are limited by their invasive nature. This review examines nanotechnological approaches to retinal diseases in a clinical context. Nanotechnology has the potential to transform pharmacological and surgical interventions by overcoming limitations posed by the protective anatomical and physiological barriers that limit access to the retina. Preclinical research in the application of nanoparticles in diagnostics indicates that nanoparticles can enhance existing diagnostic and screening tools to detect diseases earlier and more easily and improve disease progression monitoring precision.
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DOI：
10.1016/j.jconrel.2013.10.008
发表时间：
2013-12-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Iwase T;Fu J;Yoshida T;Muramatsu D;Miki A;Hashida N;Lu L;Oveson B;Lima e Silva R;Seidel C;Yang M;Connelly S;Shen J;Han B;Wu M;Semenza GL;Hanes J;Campochiaro PA
通讯作者：
Campochiaro PA
影响因子：
8
作者：
Honda M;Asai T;Oku N;Araki Y;Tanaka M;Ebihara N
通讯作者：
Ebihara N
影响因子：
3.3
作者：
Cholkar, Kishore;Gunda, Sriram;Mitra, Ashim K.
通讯作者：
Mitra, Ashim K.
影响因子：
4.8
作者：
Cai, Xue;Conley, Shannon M.;Naash, Muna I.
通讯作者：
Naash, Muna I.
影响因子：
5.5
作者：
Han, Zongchao;Koirala, Adarsha;Naash, Muna I.
通讯作者：
Naash, Muna I.