TRANSCRIPTIONAL ACTIVATION OF AN UNREARRANGED AND UNTRANSLOCATED C-MYC ONCOGENE BY TRANSLOCATION OF A C-LAMBDA LOCUS IN BURKITT-LYMPHOMA CELLS
TRANSCRIPTIONAL ACTIVATION OF AN UNREARRANGED AND UNTRANSLOCATED C-MYC ONCOGENE BY TRANSLOCATION OF A C-LAMBDA LOCUS IN BURKITT-LYMPHOMA CELLS
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DOI：
10.1073/pnas.80.22.6922
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
NOWELL, PC
中科院分区：
文献类型：
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作者：
CROCE, CM;THIERFELDER, W;NOWELL, PC
研究了小鼠骨髓瘤细胞和携带t（8;22）染色体易位的IARC-BL 2伯基特淋巴瘤人细胞之间的体细胞杂交体中人IG的存在和表达。链和c-myc癌基因。显然，c-myc癌基因保留在8 q+染色体上，而排除和重排的C. cadida。等位基因从22号染色体易位到8号染色体。易位的结果是，重排的8号染色体（8 q+）上的c-myc癌基因发生转录激活，而正常8号染色体上的c-myc癌基因在转录上沉默。重排的IG位点易位到未重排的c-myc癌基因的3“侧可增强其转录并促成恶性转化。
Somatic cell hybrids between mouse myeloma cells and IARC-BL2 Burkitt lymphoma human cells carrying a t(8;22) chromosome translocation were studied for the presence and expression of human Ig .lambda. chains and for the c-myc oncogene. Apparently, the c-myc oncogene remains on the 8q+ chromosome, and the excluded and rearranged C.lambda. allele translocates from chromosome 22 to this chromosome 8. As a result of the translocation, transcriptional activation of the c-myc oncogene on the rearranged chromosome 8 (8q+) occurs, while the c-myc oncogene in the normal chromosome 8 is transcriptionally silent. The translocation of a rearranged Ig locus to the 3'' side of an unrearranged c-myc oncogene may enhance its transcription and contribute to malignant transformation.