Differentiation of group A streptococci with a common R antigen into three serological types, with special reference to the bactericidal test.
Differentiation of group A streptococci with a common R antigen into three serological types, with special reference to the bactericidal test.
复制标题
将具有共同 R 抗原的 A 族链球菌分为三种血清学类型，特别参考杀菌试验。
DOI：
10.1084/jem.106.4.525
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发表时间：
1957-10-01
影响因子：
15.3
通讯作者：
LANCEFIELD, R C
中科院分区：
文献类型：
--
作者：
LANCEFIELD, R C
在对含有R抗原的链球菌的进一步研究中，用杀菌试验代替小鼠保护试验来研究这些细菌的型特异性M抗原。M抗M沉淀试验证实了这一结果，并表明菌株的M抗原和T抗原之间存在相关性。根据一种特定的M抗原，28型已被证明包括格里菲斯的小株和其他四种含r的菌株。以前根据R抗原反应被认为属于28型的其他一些毒株，现在被确定为属于2型或新的48型，48型与13型呈单向交叉关系。建议采用杀菌试验作为评估a组链球菌M抗原的有效方法，并通过生物试验建立类型特异性，比标准小鼠保护试验适用范围更广。
In further study of streptococci having the R antigen, the bactericidal test has been used instead of the mouse protection test in investigating the type-specific M antigens of these organisms. The results have been confirmed by M anti-M precipitin tests, and a correlation between the M and T antigens of the strains has been shown. On the basis of a specific M antigen, type 28 has been shown to comprise Griffith's strain Small and four other R-containing strains. A number of other strains previously thought to belong to type 28 on the basis of R antigen reactions have now been identified as belonging either to type 2 or to a new type, designated 48, which shows a one-way cross-relationship to type 13. The bactericidal test is suggested as a useful method for assessing M antigen in group A streptococci and for establishing type-specificity by means of a biological test which is more widely applicable than the standard mouse protection test.