Distribution of Collagen Fiber Orientation in the Human Lung
Distribution of Collagen Fiber Orientation in the Human Lung
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DOI：
10.1002/ar.22649
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发表时间：
2013-05-01
影响因子：
2
通讯作者：
Osaki, Shigeyoshi
中科院分区：
文献类型：
--
作者：
Tomoda, Koichi;Kimura, Hiroshi;Osaki, Shigeyoshi
胶原纤维是人肺中细胞外基质的主要成分，在机械地维持肺结构方面至关重要。胶原纤维的取向与其力学性能密切相关，有必要对其进行研究。在本研究中，通过大崎的微波方法定量测量了肺中胶原纤维的取向。我们成功地制备了从肺沿冠状方向切割的片状样品用于测量。结果发现，平均而言，胶原纤维的取向平行于脊柱的纵轴。使用光学显微镜观察到的肺样品中的空隙空间不是圆形而是椭圆形。椭圆形空隙的长轴方向与胶原纤维的取向一致。结果表明，胶原纤维的取向与人肺的呼吸运动密切相关。(C)2013 Wiley Periodicals，Inc.
Collagen fiber, a major component of the extracellular matrix in the human lung, is crucial in maintaining the lung structure mechanically. It is necessary to study the collagen fiber orientation which the mechanical function is closely related to. In the present study the collagen fiber orientation in the lung was quantitatively measured by Osaki's microwave method. We succeeded in preparing sheet samples cut in a coronal direction from the lung for the measurements. It was found that the collagen fibers were, on average, orientated parallel to the longitudinal axis of the spine. The void spaces in the lung sample observed using an optical microscope was not circular but ellipsoidal. The direction of the long axes of ellipsoidal voids coincided with that of the collagen fiber orientation. The results suggested that collagen fiber orientation is closely related to the respiratory movement of the human lung. (C) 2013 Wiley Periodicals, Inc.