The burden, prevention and care of infants and children with congenital anomalies in sub-Saharan Africa: A scoping review.
The burden, prevention and care of infants and children with congenital anomalies in sub-Saharan Africa: A scoping review.
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DOI：
10.1371/journal.pgph.0001850
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Barlow-Mosha, Linda
中科院分区：
文献类型：
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作者：
Leke, Aminkeng Zawuo;Malherbe, Helen;Kalk, Emma;Mehta, Ushma;Kisa, Phylis;Botto, Lorenzo D;Ayede, Idowu;Fairlie, Lee;Maboh, Nkwati Michel;Orioli, Ieda;Zash, Rebecca;Kusolo, Ronald;Mumpe-Mwanja, Daniel;Serujogi, Robert;Bongomin, Bodo;Osoro, Caroline;Dah, Clarisse;Sentumbwe-Mugisha, Olive;Shabani, Hamisi Kimaro;Musoke, Philippa;Dolk, Helen;Barlow-Mosha, Linda
本次范围界定审查的目的是确定撒哈拉以南非洲（SSA）先天性异常（CA）的范围、目标和方法，为新成立的撒哈拉以南非洲先天性异常网络（sSCAN）的活动提供信息。在MEDLINE中检索2016年1月至2021年6月期间发表的CA相关文章。文章分为四个主要领域（公共卫生负担，监测，预防，护理）和他们的目标和方法进行了总结。在识别的532篇文章中，纳入了255篇。这些文章来自49个撒哈拉以南非洲国家中的22个，其中4个国家贡献了60%的文章：尼日利亚（22.0%）、埃塞俄比亚（14.1%）、乌干达（11.7%）和南非（11.7%）。只有5.5%的研究涉及该地区的多个国家。大部分文献将CA作为其主要关注点（85%），研究单一CA（88%），重点关注CA负担（56.9%）和护理（54.1%），较少覆盖监测（3.5%）和预防（13.3%）。最常见的研究设计是病例研究/病例系列（26.6%），其次是横断面调查（17.6%），回顾性记录审查（17.3%）和队列研究（17.2%）。研究主要来自单一医院（60.4%），只有9%是基于人群的研究。大多数数据来自临床记录的回顾性审查（56.1%）或通过护理人员访谈（34.9%）获得。很少有论文包括死产（7.5%）、产前诊断的CA（3.5%）或因CA而终止妊娠（2.4%）。这项针对撒哈拉以南非洲CA的首次范围审查表明，撒哈拉以南非洲研究人员对CA的认识和认识水平不断提高对该地区5岁以下儿童死亡率和发病率的贡献。审查还强调需要解决诊断、预防、监测和护理问题，以实现可持续发展目标3.2和3.8。撒哈拉以南非洲次区域面临着独特的挑战，包括我们希望通过多学科和多利益攸关方的方法通过sSCAN克服的分散努力。
The aim of this scoping review was to determine the scope, objectives and methodology of contemporary published research on congenital anomalies (CAs) in sub-Saharan Africa (SSA), to inform activities of the newly established sub-Saharan African Congenital Anomaly Network (sSCAN). MEDLINE was searched for CA-related articles published between January 2016 and June 2021. Articles were classified into four main areas (public health burden, surveillance, prevention, care) and their objectives and methodologies summarized. Of the 532 articles identified, 255 were included. The articles originated from 22 of the 49 SSA countries, with four countries contributing 60% of the articles: Nigeria (22.0%), Ethiopia (14.1%), Uganda (11.7%) and South Africa (11.7%). Only 5.5% of studies involved multiple countries within the region. Most articles included CA as their primary focus (85%), investigated a single CA (88%), focused on CA burden (56.9%) and care (54.1%), with less coverage of surveillance (3.5%) and prevention (13.3%). The most common study designs were case studies/case series (26.6%), followed by cross-sectional surveys (17.6%), retrospective record reviews (17.3%), and cohort studies (17.2%). Studies were mainly derived from single hospitals (60.4%), with only 9% being population-based studies. Most data were obtained from retrospective review of clinical records (56.1%) or via caregiver interviews (34.9%). Few papers included stillbirths (7.5%), prenatally diagnosed CAs (3.5%) or terminations of pregnancy for CA (2.4%).This first-of-a-kind-scoping review on CA in SSA demonstrated an increasing level of awareness and recognition among researchers in SSA of the contribution of CAs to under-5 mortality and morbidity in the region. The review also highlighted the need to address diagnosis, prevention, surveillance and care to meet Sustainable Development Goals 3.2 and 3.8. The SSA sub-region faces unique challenges, including fragmentation of efforts that we hope to surmount through sSCAN via a multidisciplinary and multi-stakeholder approach.