Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia
Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia
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DOI：
10.1074/jbc.m111.324616
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发表时间：
2012-03-30
影响因子：
4.8
通讯作者：
Igarashi, Yasuyuki
中科院分区：
文献类型：
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作者：
Yuyama, Kohei;Sun, Hui;Igarashi, Yasuyuki
背景资料：Exosome是一种由神经元等多种细胞释放的膜泡。结果：神经元exosome促进A β纤维形成，exosome相关的A β被小胶质细胞降解。结论：exosome促进A β清除。意义：这些发现提供了exosome在脑中的新功能，也提示其参与阿尔茨海默病的发展。
Background: Exosome is a membrane vesicle released from several types of cells, including neurons.Results: Neuronal exosomes accelerate A beta fibril formation, and the exosome-associated A beta is taken into microglia to degrade it.Conclusion: Exosomes promote A beta clearance.Significance: These findings provide a new function of exosome in the brain and also suggest its involvement in the development of Alzheimer disease.