Aberrant crypts, putative precancerous lesions, in the study of the role of diet in the aetiology of colon cancer.
Aberrant crypts, putative precancerous lesions, in the study of the role of diet in the aetiology of colon cancer.
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饮食在结肠癌病因学中的作用研究中的异常隐窝，假定的癌前病变。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
W. Bruce
中科院分区：
文献类型：
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作者：
R. Bird;E. McLellan;W. Bruce
如果能开发出一种方法，对结肠癌的早期前驱病变进行鉴定和定量，将大大促进饮食和结肠癌领域的进展。最近，我们描述了一种方法（Bird，1987），该方法包括用亚甲蓝对固定的、未切片的结肠进行染色，以便在光学显微镜的帮助下观察粘膜表面。用这种方法，我们观察到早期局灶性病变的啮齿类动物的结肠已与结肠致癌剂治疗，但没有病变的对照啮齿类动物的结肠。我们称这些病变为异常隐窝（AC）。根据我们的初步观察，我们假设AC代表结肠癌的前驱病变。我们随后的研究结果（在本文中总结）支持这一论点。因此，我们建议，AC的特性的评价将进一步我们的致癌过程的理解，因为它发生在啮齿动物结肠，并将提供一个基础的调查饮食中的作用，在疾病的病因学。
Progress in the field of diet and colon cancer would be greatly enhanced by the development of a methodology which allowed for the identification and quantification of the early precursor lesions of colon cancer. Recently we described a method (Bird, 1987) consisting of staining the fixed, unsectioned colon with methylene blue for viewing the mucosal surface with the aid of a light microscope. With this methodology we observed early focal lesions in the colons of rodents which had been treated with a colon carcinogen but no lesions in the colons of control rodents. We termed these lesions aberrant crypts (AC). Based on our preliminary observations we hypothesized that AC represent precursor lesions of colon cancer. The findings from our subsequent studies (summarized in this paper) support this contention. We therefore suggest that evaluation of the characteristics of AC will further our understanding of the carcinogenic process as it occurs in the rodent colon and will provide a basis for the investigation of the role of diet in the aetiology of the disease.