Comparative Changes in Segmental Vascular Resistance in Response to Nerve Stimulation and to Norepinephrine
Comparative Changes in Segmental Vascular Resistance in Response to Nerve Stimulation and to Norepinephrine
复制标题
神经刺激和去甲肾上腺素反应的节段血管阻力的比较变化
DOI：
10.1161/01.res.18.3.263
复制
发表时间：
1966
影响因子：
20.1
通讯作者：
J. W. Eckstein
中科院分区：
文献类型：
--
作者：
F. Abboud;J. W. Eckstein
采用小血管插管法和恒血流法比较了刺激交感神经纤维和动脉内注射去甲肾上腺素对灌注犬前腿肌肉和足部血管压力和阻力的影响。可以得出以下结论：交感神经刺激主要引起大动脉段收缩。缩窄似乎在腕骨处最为严重。2. 在腕骨水平处的大动脉收缩使血流从脚掌转移到前腿更近端的肌肉部位。3. 神经刺激引起的节段性血管阻力的变化在爪和肌肉上是不同的。在爪中，静脉段明显收缩，而小血管段通常扩张并可能最小程度地收缩；但在肌肉中，动脉和小血管段比静脉段收缩更大。4. 去甲肾上腺素的作用不同于神经刺激。去甲肾上腺素主要引起掌部小血管收缩。足部小血管和静脉节的收缩超过相应肌肉节的收缩。
The effects of stimulating sympathetic nerve fibers and of intra-arterial norepinephrine on vascular pressures and resistances in muscle and paw of perfused forelegs of dogs were compared by means of small vessel cannulations and during constant blood flow. The following conclusions may be drawn: 1. Sympathetic nerve stimulation causes constriction of the large artery segment predominantly. The constriction appears to be most intense at the level of the carpus. 2. The large artery constriction at the level of the carpus diverts blood flow away from the paw and into more proximal muscular parts of the foreleg. 3. Changes in segmental vascular resistances during nerve stimulation differ in paw and muscle. In the paw, venous segments constrict markedly whereas small vessel segments usually dilate and may constrict minimally; but in the muscle, arterial and small vessel segments constrict more than venous segments. 4. The effects of norepinephrine differ from those of nerve stimulation. Norepinephrine causes constriction of small vessels in paw predominantly. Constriction of both small vessel and venous segments in paw exceeds constriction of corresponding segments in muscle.