Ocular abnormalities in congenital cytomegalovirus infection.
Ocular abnormalities in congenital cytomegalovirus infection.
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发表时间：
1996-05
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通讯作者：
Anderson Ks;Catherine S. Amos;S. Boppana;R. F. Pass
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作者：
Anderson Ks;Catherine S. Amos;S. Boppana;R. F. Pass
背景先天性巨细胞病毒（CMV）感染常导致脑、听觉和视觉系统的损害，导致虚弱。本报告描述了先天性巨细胞病毒感染儿童的眼部异常的频率、严重程度和对视觉功能的影响。方法对445例1个月~ 9岁的先天性CMV感染的婴幼儿进行一系列眼部检查，评估解剖完整性、运动感觉功能、视网膜和后极。结果眼部疾病主要表现为脉络膜视网膜炎、视神经萎缩、色素性视网膜病变和斜视;这些发现在出生时有症状的儿童中比在最初无症状的儿童中更常见（p < 0.05）。这些相同的发现在原发性母体感染后出生的患者中也比在复发性母体感染后出生的患者中更常见。超过一半的有症状的先天性CMV感染伴脉络膜视网膜炎或视神经萎缩的患者有明显的双眼视觉障碍。结论眼部疾病是先天性CMV感染的重要后遗症，可导致视力受损。为了允许早期干预，先天性CMV感染的患者应在婴儿早期开始进行眼部检查。
BACKGROUND Congenital cytomegalovirus (CMV) infection often results in damage to the brain, auditory system and visual system that leads to debility. This report describes the frequency, severity and effect on vision function of ocular abnormalities in a large cohort of children with congenital CMV infection. METHODS Serial eye examinations were performed on 445 infants and children with congenital CMV infection from one month to 9 years of age, assessing anatomic integrity, motor sensory function, retina and posterior pole. RESULTS Ocular disease was manifest principally by chorioretinitis, optic atrophy, pigmentary retinopathy and strabismus; each of these findings occurred more frequently (p < 0.05) among children who were symptomatic at birth than among those who were initially asymptomatic. These same findings were also more common among patients born after a primary maternal infection than among those born after a recurrent maternal infection. More than half of the patients with symptomatic congenital CMV infection with chorioretinitis or optic atrophy had significant binocular vision impairment. CONCLUSIONS Ocular disease is an important sequela of congenital CMV infection that can lead to impaired vision. In order to allow for early intervention, patients with congenital CMV infection should have eye examinations beginning in early infancy.