Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach.
Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach.
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DOI：
10.1053/j.gastro.2016.12.001
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发表时间：
2017-03
期刊：
影响因子：
29.4
通讯作者：
Mills JC
中科院分区：
文献类型：
--
作者：
Burclaff J;Osaki LH;Liu D;Goldenring JR;Mills JC
壁细胞萎缩被认为是导致胃化生的原因。我们开发了在壁细胞中特异性表达白喉毒素受体以诱导其死亡的小鼠，并发现这会增加正常干细胞区和颈部的增殖，但不会引起主细胞的化生重编程。此外，化生诱导剂他莫昔芬或DMP-777即使在先前被白喉毒素破坏壁细胞后仍然诱导化生。因此，仅壁细胞萎缩不足以诱导化生——主细胞化生重编程的完成需要壁细胞损伤或死亡之外的机制。
Parietal cell atrophy is considered to cause metaplasia in the stomach. We developed mice that express the diphtheria toxin receptor specifically in parietal cells to induce their death, and found this to increase proliferation in the normal stem cell zone and neck but not to cause metaplastic reprogramming of chief cells. Furthermore, the metaplasia-inducing agents tamoxifen or DMP-777 still induced metaplasia even following previous destruction of parietal cells by diphtheria toxin. Atrophy of parietal cells alone is therefore not sufficient to induce metaplasia—completion of metaplastic reprogramming of chief cells requires mechanisms beyond parietal cell injury or death.