Antibacterial activity of an eudesmane sesquiterpene isolated from common Varthemia, Varthemia iphionoides
Antibacterial activity of an eudesmane sesquiterpene isolated from common Varthemia, Varthemia iphionoides
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DOI：
10.1016/j.jep.2004.11.007
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发表时间：
2005-02-28
影响因子：
5.4
通讯作者：
Hayashi, H
中科院分区：
文献类型：
--
作者：
Al-Dabbas, MM;Hashinaga, F;Hayashi, H
菊科植物灯笼草的乙酸乙酯提取物具有明显的抑菌活性。乙酸乙酯提取物的生物测定引导的分级分离和最具抗菌活性的级分的进一步纯化导致抗菌倍半萜，selina-4，11（13）-二烯-3-酮-12-酸的分离和鉴定。该化合物对六种细菌（金黄色葡萄球菌、枯草芽孢杆菌、藤黄微球菌、大肠杆菌、枯草芽孢杆菌和沙门氏菌）具有有效的抗菌活性。通过琼脂稀释法测定的该化合物的最小抑制浓度（MIC）在250和500 μ g/ml之间。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
The ethyl acetate extract of the whole aerial parts of Varthemia iphionoides (Compositae) showed a pronounced antibacterial activity. The bioassay-guided fractionation of the ethyl acetate extract and further purification of the most antibacterially active fraction led to the isolation and identification of an antibacterial sesquiterpene, selina-4,11(13)-dien-3-on-12-oic acid. This compound exhibited potent antimicrobial activity against six bacterial species (Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Escherichia coli, Bacillus cercus and Salmonella enteritides). The minimum inhibitory concentrations (MICs) of this compound which was determined by the agar dilution method ranged between 250 and 500 mug/ml. (C) 2004 Elsevier Ireland Ltd. All rights reserved.