Explaining multiple sclerosis prevalence by ultraviolet exposure: a geospatial analysis
Explaining multiple sclerosis prevalence by ultraviolet exposure: a geospatial analysis
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DOI：
10.1177/1352458509105579
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发表时间：
2009-08-01
影响因子：
5.8
通讯作者：
Beretich, T. M.
中科院分区：
文献类型：
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作者：
Beretich, B. D.;Beretich, T. M.
背景流行病学研究显示多发性硬化（MS）患病率与纬度呈正相关。然而，在这方面，没有发现因果关系。增加饮食摄入量和增加血清维生素D水平显示出对MS的发展具有保护作用。紫外线（UV）紫外线辐射在维生素D合成中起着重要作用，可能解释MS患病率的纬度差异以及MS患者维生素D水平低的原因。目的探讨紫外线辐射与MS患病率的关系方法对北美地区和美国大陆分别进行地理空间分析。计算了紫外线辐射（以紫外线指数[UVI]衡量）与MS患病率的相关性以及紫外线辐射与病例对照比的相关性。结果美国各州的病例对照比和北美地区的MS患病率与UVI呈显著负相关（R分别为-0.72和-0.86）。五个最高风险状态/最低UVI与五个最低风险状态/最高UVI的RR增加（RR = 1.8-5.4）。在UVI最低和最高的北美地区，MS的RR为3.78，而在美国地区，RR为1.52。结论UV辐射与MS的分布密切相关，在UVI较低的地区，MS的危险性增加。多发性硬化2009; 15：891-898. http://msj.sagepub.com
Background Epidemiologic studies have shown a positive correlation of multiple sclerosis ( MS) prevalence with latitude. However, there has not been a causal association found. Increased dietary intake and increased serum levels of vitamin D showed to be protective for the development of MS. Ultraviolet (UV) radiation plays an important role in vitamin D synthesis and could potentially explain both latitude differences in MS prevalence and the low levels of vitamin D in individuals with MS.Objective To evaluate the relationship between UV radiation and MS prevalence using geospatial analysis.Methods Geospatial analysis was performed on North American regions and separately for the continental United States. The correlation of UV radiation (measured as UV index [UVI]) versus MS prevalence and UV radiation versus case-control ratios was calculated. In addition, the relative risk (RR) of MS was determined for regions/states with low UV radiation exposure.Results Case-control ratios by US state and MS prevalence by North American region showed a strong negative (inverse) correlation with UVI (R = -0.72 and -0.86, respectively). The RR for the five highest risk states/lowest UVI versus the five lowest risk states/highest UVI was increased (RR = 1.8-5.4). The RR for MS, when comparing North American regions with lowest and highest UVI, was 3.78 and within US regions was 1.52.Conclusion This analysis suggests a strong association between UV radiation and MS distribution, and an increase in risk for MS in those areas with a low UVI. Multiple Sclerosis 2009; 15: 891-898. http://msj.sagepub.com