Association study between RGS4 and bipolar disorder in the Chinese Han population
Association study between RGS4 and bipolar disorder in the Chinese Han population
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RGS4与中国汉族人群双相情感障碍的关联研究
DOI：
10.1097/ypg.0b013e32833a2009
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发表时间：
2010
影响因子：
0.9
通讯作者：
Yongyong Shi
中科院分区：
文献类型：
--
作者：
You Li;Qian Zhao;Zhao Zhang;Pengkun Wang;R. Che;Wei Tang;G. Feng;K. Lindpaintner;Lin He;Yongyong Shi
本摘要涉及RGS4与双相情感障碍之间的简要关联研究，通过对来自中国汉族人群的484名患者和288名对照者的5个单核苷酸多态性rs951436、rs951439、rs2842030、rs2661319和rs2344671进行关联研究。在我们的病例对照研究中，单核苷酸多态性rs951436的T等位基因倾向于保护（P=0.0078），此外，包含该T等位基因的单倍型也对双相情感障碍具有保护作用（P=0.02）。我们的研究结果提供了进一步的证据，支持RGS4作为一个潜在的易感基因的双相情感障碍。
This abstract concerns a brief association study between RGS4 and bipolar disorder, by an association study of five single nucleotide polymorphisms, rs951436, rs951439, rs2842030, rs2661319, and rs2344671, in 484 patients and 288 controls from the Chinese Han population. In our case–control study, the T allele of the single nucleotide polymorphism rs951436 tended to be protective (P=0.0078), and in addition, a haplotype containing this T allele was also protective for bipolar disorder (P=0.02). Our results provide further evidence to support RGS4 as a potential susceptible gene for bipolar disorder.