Loud sound-induced changes in cochlear mechanics.
Loud sound-induced changes in cochlear mechanics.
复制标题
大声的声音引起的耳蜗力学变化。
DOI：
10.1152/jn.00192.2002
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发表时间：
2002
影响因子：
2.5
通讯作者：
Nuttall,Alfred
中科院分区：
文献类型：
--
作者：
Fridberger,Anders;Zheng,Jiefu;Parthasarathi,Anand;Ren,Tianying;Nuttall,Alfred
为了研究内耳对强声的反应和暂时性听阈偏移的机制，麻醉豚鼠暴露于100-112 dB SPL的音调。采用激光测速仪测量基底膜振动，并将耳蜗微音电位、听神经复合动作电位和Corti器局部交流电位作为耳蜗功能的附加指标。暴露于12 kHz的强音后，基底膜振动响应于探测音在记录位置的特征频率（17 kHz）被暂时减少。在大多数情况下，这种减少在50 ms的过程中恢复。Corti器AC电位也降低，恢复的时间过程与基底膜相似。当使用1或4 kHz的探头音时，Corti器官AC电位不受响亮声音的影响，表明换能器通道保持完整。在大多数实验中，基底膜和耳蜗颤噪反应的12 kHz的过度刺激是恒定的整个持续时间的强烈刺激，尽管耳蜗灵敏度的大损失。它的结论是降低基底膜速度，随后响亮的声音是由耳蜗放大的变化，耳蜗对强烈刺激的反应是由内耳结构的被动力学性能。
To investigate the inner ear response to intense sound and the mechanisms behind temporary threshold shifts, anesthetized guinea pigs were exposed to tones at 100–112 dB SPL. Basilar membrane vibration was measured using laser velocimetry, and the cochlear microphonic potential, compound action potential of the auditory nerve, and local electric AC potentials in the organ of Corti were used as additional indicators of cochlear function. After exposure to a 12-kHz intense tone, basilar membrane vibrations in response to probe tones at the characteristic frequency of the recording location (17 kHz) were transiently reduced. This reduction recovered over the course of 50 ms in most cases. Organ of Corti AC potentials were also reduced and recovered with a time course similar to the basilar membrane. When using a probe tone at either 1 or 4 kHz, organ of Corti AC potentials were unaffected by loud sound, indicating that transducer channels remained intact. In most experiments, both the basilar membrane and the cochlear microphonic response to the 12-kHz overstimulation was constant throughout the duration of the intense stimulus, despite a large loss of cochlear sensitivity. It is concluded that the reduction of basilar membrane velocity that followed loud sound was caused by changes in cochlear amplification and that the cochlear response to intense stimulation is determined by the passive mechanical properties of the inner ear structures.
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听力灵敏度的生物力学
DOI：
--
发表时间：
1991
期刊：
影响因子：
--
作者：
Sir James Lighthill
通讯作者：
Sir James Lighthill
影响因子：
2.8
作者：
R. Patuzzi;B. M. Johnstone;P. Sellick
通讯作者：
P. Sellick
影响因子：
2.8
作者：
PATUZZI, RB;YATES, GK;JOHNSTONE, BM
通讯作者：
JOHNSTONE, BM
两种音调交互中的耳蜗麦克风增强
影响因子：
2.8
作者：
A. Nuttall;D. Dolan
通讯作者：
D. Dolan
影响因子：
2.8
作者：
CODY, AR;JOHNSTONE, BM
通讯作者：
JOHNSTONE, BM