Variability in determination of body weight used for dosing busulphan and cyclophosphamide in adult patients: Results of an international survey
Variability in determination of body weight used for dosing busulphan and cyclophosphamide in adult patients: Results of an international survey
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DOI：
10.3109/10428199709039036
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发表时间：
1997-05-01
影响因子：
2.6
通讯作者：
Szer, J
中科院分区：
文献类型：
--
作者：
Grigg, A;Harun, MH;Szer, J
52 家 BMT 机构： 发送了一份调查问卷，询问白消安、环磷酰胺 (bu-cy)、环孢素和甲氨蝶呤 (CSA-MTX) 的剂量详情。要求提供以下数据：（a）用于确定体重以进行剂量计算的方法（b）单位体重的实际剂量和（c）给药时间表。 36 所 (69%) 机构作出回应，其中 33 所可评估。用于确定 bu-cy 重量的方法存在很大差异。尽管大多数单位考虑到实际体重与理想体重之间的差异，但没有超过 30% 的单位使用单一方法。 CSA-MTX的体重测定方法更加统一，大多数单位使用实际体重。相反，与 bu-cy 相比，CSA-MTX 所用的单位体重剂量配方和时间表的变化要大得多。这些实质性差异凸显了在报告化疗方案的毒性和疗效时指定这些标准的重要性，以及需要进一步研究以确定剂量计算的最佳重量公式。
Fifty-two BMT institutions were: sent a questionnaire asking for details of dosing for busulphan, cyclophosphamide (bu-cy), cyclosporin and methotrexate (CSA-MTX). The following data were requested: (a) the method used to determine the body weight for dosage calculations (b) the actual dose per weight and (c) the schedule of administration. Thirty-six (69%) institutions responded and 33 were evaluable. There was substantial variation in the method used to determine weight for bu-cy. No single method was used in more than 30% of units, although most units made some allowance for discrepancies between actual and ideal body weight. There was more uniformity in the method of weight determination for CSA-MTX, with the majority of units using actual body weight. Conversely, there was much more Variation in the dose per weight formulae and schedules used for CSA-MTX than for bu-cy. These substantial differences highlight the importance of specifying these criteria when the toxicity and efficacy of chemotherapy regimens is reported and the need for further studies to determine the optimal weight formulae for dosage calculations.