Transdiagnostic dimensions of symptoms and experiences associated with immune proteins in the continuity of psychosis
Transdiagnostic dimensions of symptoms and experiences associated with immune proteins in the continuity of psychosis
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DOI：
10.1017/s0033291724000199
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发表时间：
2024-02-28
影响因子：
6.9
通讯作者：
Del-Ben，Cristina Marta
中科院分区：
文献类型：
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作者：
Corsi-Zuelli，Fabiana;Quattrone，Diego;Del-Ben，Cristina Marta
BackgroundThere是有限的证据，以是否与一个特定的psychosis continuous.MethodsWe的psychosis模式与免疫蛋白质的一般和特定的尺寸的精神病患者（n = 52）和社区对照组（n = 200）的兄弟姐妹的经验，并在首发精神病（FEP）患者（n = 110）的精神病症状，估计两个双因素模型。我们评估了这些转诊断维度与性状（TNF-α、IFN-γ）、状态（IL-6、IL-1β）和调节性（TGF-β、IL-10、IL-4）细胞因子之间的关联。我们探讨了精神分裂症的遗传倾向（精神分裂症多基因风险评分; SZ-PRS）修改association.ResultsHigh水平的性状标记IFN-γ与一般精神病维度的严重程度在未受影响的兄弟姐妹和社区控制，扩展到抑郁维度的兄弟姐妹和躁狂维度的FEP。高TNF-α水平与未受影响的兄弟姐妹中更积极的精神病经历和FEP中的躁狂症状相关。低水平的状态标志物IL-6和IL-1β在未受影响的兄弟姐妹中观察到更多的抑郁经历。尽管如此，高水平的IL-6和IL-1β与FEP时抑郁和阴性症状维度的严重程度相关。三组间的跨诊断维度评分的严重程度与较低的调节性细胞因子相关。探索性分析表明，一个高的SZ-PRS主要贡献协会与精神病dimensions.ConclusionsIFN-γ映射到精神病的多维表达，加强特质的概念。状态标志物IL-6和IL-1β可能沿着谱波动。调节臂的功能障碍可能会抑制炎症系统。与精神病性维度的关联可能更倾向于SZ-PRS易感性。
BackgroundThere is limited evidence as to whether the immune protein profile is associated with a particular symptomatology pattern across the psychosis continuum.MethodsWe estimated two bifactor models of general and specific dimensions of psychotic experiences in unaffected siblings of patients (n = 52) and community controls (n = 200), and of psychotic symptoms in first-episode psychosis (FEP) patients (n = 110). We evaluated associations between these transdiagnostic dimensions and trait (TNF-α, IFN-γ), state (IL-6, IL-1β), and regulatory (TGF-β, IL-10, IL-4) cytokines. We explored whether schizophrenia genetic liability (schizophrenia polygenic risk score; SZ-PRS) modified the associations.ResultsHigh levels of trait marker IFN-γ were associated with the severity of general psychosis dimension in the unaffected siblings and community controls, expanding to the depressive dimension in siblings and to the manic dimension in FEP. High TNF-α levels were associated with more positive psychotic experiences in unaffected siblings and manic symptoms in FEP. Low levels of state markers IL-6 and IL-1β were observed in unaffected siblings presenting more depressive experiences. Still, high levels of IL-6 and IL-1β were associated with the severity of the depressive and negative symptom dimensions at FEP. The severity of transdiagnostic dimension scores across the three groups was associated with lower regulatory cytokines. Exploratory analysis suggested that a high SZ-PRS contributed mostly to associations with psychotic dimensions.ConclusionsIFN-γ mapped onto the multidimensional expression of psychosis, reinforcing the trait concept. State markers IL-6 and IL-1β may fluctuate along the spectrum. Dysfunction in the regulatory arm may disinhibit the inflammatory system. Associations with psychotic dimensions may be more prone to SZ-PRS susceptibility.