You've gotta know when to fold 'Em: Goal disengagement and systemic inflammation in adolescence
You've gotta know when to fold 'Em: Goal disengagement and systemic inflammation in adolescence
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DOI：
10.1111/j.1467-9280.2007.01977.x
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发表时间：
2007-09-01
影响因子：
8.2
通讯作者：
Wrosch, Carsten
中科院分区：
文献类型：
--
作者：
Miller, Gregory E.;Wrosch, Carsten
坚持是成功和幸福的关键，这一概念深深植根于流行和科学著作中。然而，当人们面临无法实现关键人生目标的情况时，对身心健康最具适应性的反应可能是脱离该目标。该项目在一年的时间里跟踪了90名青少年。在基线时评估管理无法实现的目标的能力，并在当时以及6个月和12个月后定量炎症分子C反应蛋白（CRP）的浓度。在受试者难以脱离无法实现的目标的程度上，他们在随访期间显示CRP浓度增加。这种关联与潜在的混淆无关，包括肥胖、吸烟和抑郁。由于过度的炎症会导致各种不良的医疗结果，这些发现表明，在某些情况下，持久性实际上可能会破坏幸福和健康。
The notion that persistence is essential for success and happiness is deeply embedded in popular and scientific writings. However, when people are faced with situations in which they cannot realize a key life goal, the most adaptive response for mental and physical health may be to disengage from that goal. This project followed 90 adolescents over the course of 1 year. Capacities for managing unattainable goals were assessed at baseline, and concentrations of the inflammatory molecule C-reactive protein (CRP) were quantified at that time, as well as 6 and 12 months later. To the extent that subjects had difficulties disengaging from unattainable goals, they displayed increasing concentrations of CRP over the follow-up. This association was independent of potential confounds, including adiposity, smoking, and depression. Because excessive inflammation contributes to a variety of adverse medical outcomes, these findings suggest that in some contexts, persistence may actually undermine well-being and good health.