Synthesis of 6-Se-guanosine RNAs for structural study.
Synthesis of 6-Se-guanosine RNAs for structural study.
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用于结构研究的 6-Se-鸟苷 RNA 的合成。
DOI：
10.1021/ol401698n
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发表时间：
2013
期刊：
影响因子：
5.2
通讯作者：
Huang,Zhen
中科院分区：
文献类型：
--
作者：
Salon,Jozef;Gan,Jianhua;Abdur,Rob;Liu,Hehua;Huang,Zhen
通过硒取代6-氧原子合成了6-Se-鸟苷亚磷酰胺和RNA，发现Se-衍生化相对稳定，凸起和摆动结构比双链体更能容纳大的Se原子。这种硒修饰在RNA及其蛋白质复合物的结构研究中是有用的。
6-Se-guanosine phosphoramidite and RNAs have been synthesized by selenium substitution of the 6-oxygen atom, and it is revealed that the Se-derivatization is relatively stable and that bulge and wobble structures can better accommodate a large Se atom than a duplex. This Se-modification is useful in the structural study of RNAs and their protein complexes.