Influence of microdamage on fracture toughness of the human femur and tibia
Influence of microdamage on fracture toughness of the human femur and tibia
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DOI：
10.1016/s8756-3282(98)00103-3
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发表时间：
1998-09-01
期刊：
影响因子：
4.1
通讯作者：
Wang, Z
中科院分区：
文献类型：
--
作者：
Norman, TL;Yeni, YN;Wang, Z
微损伤累积和骨脆性之间的关系还不清楚。以前的工作已经证明了人类皮质骨的微损伤和年龄之间的正相关关系。先前的研究也表明，断裂韧性随着年龄的增长而降低。基于这些研究结果，本研究的目的是测试的假设，断裂韧性的降低可以归因于微损伤密度的增加。微损伤参数测量了取自人股骨和胫骨干的骨的微损伤参数（密度、表面密度和平均裂纹长度），并与同一骨的断裂韧性测试结果进行了相关性分析。结果表明，在拉伸载荷下，股骨的断裂韧性与微损伤参数之间存在微弱但显著的负相关关系，这些发现表明，在透射光水平（100倍）下观察到的体内微损伤对其他导致断裂韧性随年龄降低的因素起次要作用。结果还表明，这种关系取决于股骨和胫骨之间明显不同的骨韧性。除了之前的调查之外，这项研究还表明，裂纹尺寸（微观与亚微观）和裂纹起源或类型（体内与应力诱导从头开始）可能会影响微观损伤和骨韧性之间的关系。(Bone 23：303-306; 1998）（C）1998，Elsevier Science Inc. All rights reserved.
The relationship between microdamage accumulation and bone fragility is not well understood. Previous work has demonstrated a positive relationship between microdamage and age in human cortical bone. Prior investigations have also demonstrated that fracture toughness decreases with age in the same bone. Based on these findings, the objective of this study was to test the hypothesis that a decrease in fracture toughness can be attributed to an increase in microdamage density. Microdamage parameters (density, surface density, and average crack length) were measured from bone taken from the shaft of the human femur and tibia and correlated with results from fracture toughness tests of the same bone, Results indicated that there was a weak but significant inverse relationship between fracture toughness and microdamage parameters for tension loading of the femur, These findings suggest that in vivo microdamage observable at the transmitted light level (100x) plays a secondary role to other contributory factors to decreased fracture toughness with age. Results also indicate that this relationship depends on bone ductility that apparently differs between the femur and the tibia, This study, in addition to prior investigations, suggests that crack size (microscopic vs. submicroscopic) and crack origin or type (in vivo vs. stress induced de novo) may influence the relationship between microdamage and bone toughness. (Bone 23:303-306; 1998) (C) 1998 by Elsevier Science Inc. All rights reserved.