Neuroprotective effects of a systemically active Group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia
Neuroprotective effects of a systemically active Group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia
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DOI：
10.1097/00001756-199804200-00042
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发表时间：
1998-04-20
期刊：
影响因子：
1.7
通讯作者：
Lodge, D
中科院分区：
文献类型：
--
作者：
Bond, A;O'Neill, MJ;Lodge, D
在沙土鼠全脑缺血模型中，评价了一种新型的II组代谢性谷氨酸受体激动剂LY354740的神经保护作用。在双侧颈总动脉结扎(BCAO)3min后给药50 mg/kg、30min和6h，可明显减轻CA1区海马神经元的损伤。缺血时间延长至4min和5min时，LY354740的神经保护作用减弱。从这些发现看来，第二组mGluRs可能在沙土鼠海马区的缺血性损伤中发挥作用，这些受体的激动剂是潜在的神经保护剂。(C)1998年Rapid Science Ltd.
THE neuroprotective effects of a novel Group II metabotropic glutamate receptor (mGluR) agonist, LY354740, have been evaluated in a gerbil model of global ischaemia. When administered at 50 mg/kg, i.p., 30 min and 6 h after a 3 min period of bilateral carotid artery occlusion (BCAO), the compound reduced the damage to CA1 hippocampal neurones to a significant level. However, when the ischaemic insult was made more severe, by increasing the period of occlusion to 4 and 5 min, the neuroprotective effects of LY354740 were reduced. From these findings, it would appear that Group II mGluRs may play a role in ischaemic damage in the gerbil hippocampus and that agonists at these receptors are potential neuroprotective agents. (C) 1998 Rapid Science Ltd.