Novel frontiers in ultra-structural and molecular MRI of the brain.
Novel frontiers in ultra-structural and molecular MRI of the brain.
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DOI：
10.1097/wco.0b013e328348972a
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发表时间：
2011-08
影响因子：
4.8
通讯作者：
Koretsky AP
中科院分区：
文献类型：
--
作者：
Duyn JH;Koretsky AP
在大脑图像中使用MRI对比度的最新进展继续扩大了MRI在神经科学中的使用。更高的磁场强度和创新的对比度处理方法使脑组织的各种属性得到了更好的可视化，有助于从解剖学上定义功能区及其白质纤维连接。这使我们更接近于了解大脑的进化蓝图，改进了对疾病的检测和表征，并有助于指导治疗。本文重点介绍了磁化率造影剂在白质纤维和皮质层研究中的应用，以及内源性和外源性造影剂在细胞事件研究中的应用。
Recent developments in the use of MRI contrast in images of the brain continue to expand the use of MRI in neuroscience. Higher magnetic field strengths and innovative ways to manipulate contrast have allowed improved visualization of the various properties of brain tissues, facilitating the anatomical definition of functional areas and their white matter fiber connections. This is bringing us closer to understanding the evolutionary blueprint of the brain, improving the detection and characterization of disease, and help guiding treatment. This review highlights some areas of recent progress, including the application of magnetic susceptibility contrast to study white matter fibers and cortical layers and the use of endogenous and exogenous contrast to study cellular events.