Association between anxiety disorders and substance use disorders among young persons: results of a 21-year longitudinal study
Association between anxiety disorders and substance use disorders among young persons: results of a 21-year longitudinal study
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DOI：
10.1016/j.jpsychires.2003.09.002
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发表时间：
2004-05-01
影响因子：
4.8
通讯作者：
Horwood, LJ
中科院分区：
文献类型：
--
作者：
Goodwin, RD;Fergusson, DM;Horwood, LJ
目的：研究焦虑障碍与物质使用障碍之间的联系，对一组研究至成年的年轻人进行研究。方法：通过对1000多名新西兰出生的年轻人的出生队列的纵向研究收集数据。在研究过程中，收集了以下数据：(A)16-18岁和18-21岁的焦虑症和药物使用障碍；(B)一系列潜在的混杂因素，包括童年、社会和家庭因素的测量。结果：患有焦虑症的年轻人发生物质依赖的几率是没有焦虑症的年轻人的1.3到3.9倍。这些联系在很大程度上是由一系列协变量因素解释的，这些因素涉及：(A)童年和家庭因素；(B)先前的物质依赖；(C)共病抑郁；(D)同伴关系。在调整了这些因素后，焦虑症与所有物质使用指标无关。结论：患有焦虑症的年轻人物质依赖的风险增加。然而，这种关联似乎在很大程度上或完全是非因果的，反映了童年因素、既往物质依赖、共病抑郁、同伴关系和焦虑症的发展之间的关联。(C)2003爱思唯尔有限公司。保留所有权利。
Objective: To examine the linkages between anxiety disorders and the development of substance use disorders in a birth cohort of young people studied to young adulthood. Method: Data were gathered over the course of a longitudinal study of a birth cohort of over 1000 New Zealand born young people. Over the course of the study, data were gathered on: (a) anxiety disorders and substance use disorders at ages 16-18 and 18-21; (b) a range of potential confounding factors including measures of childhood, social, and family factors. Results: Young people with anxiety disorders had odds of substance dependence that were between 1.3 and 3.9 times higher than young people without anxiety disorders. These associations were largely explained by a series of covariate factors relating to: (a) childhood and family factors; (b) prior substance dependence; (c) comorbid depression; (d) peer affiliations. After adjustment for these factors, anxiety disorder was unrelated to all measures of substance use. Conclusions: Young people with anxiety disorders are at increased risk of substance dependence. However, this association appears to be largely or wholly non causal and reflects the associations between childhood factors, prior substance dependence, comorbid depression, peer affiliations and the development of anxiety disorders. (C) 2003 Elsevier Ltd. All rights reserved.